Maintain 100% production uptime with Exbiol® global stock. 18,000kg ready-to-ship. 3-day lead time. Standard 25kg drums optimized for high-speed automated lines.
Validate stability with our Redox-Shield Technical Dossier. Industry-leading Toluene-Free profile. Verified Specific Optical Rotation [-15.5° to -17.5°].
1. What is Reduced L-Glutathione (GSH)?
Reduced L-Glutathione is a tripeptide composed of Glutamate, Cysteine, and Glycine. In the industrial sector, it is recognized as the “Master Antioxidant” isolate. Unlike the oxidized form (GSSG), Exbiol® Reduced Glutathione provides the high electron-donor capacity required for active cellular redox cycles. Our manufacturing focus is on polymorphic crystalline stability and the elimination of aromatic solvents like Toluene, fulfilling the clean-label demands of Tier-1 global glutathione supplier networks.
2. Technical Specifications
Pharma-grade crystalline isolate. High molecular stability confirmed via 40°C accelerated stress tests. Melting range: 189°C — 193°C.
3. Source & Manufacturing Origin
Exbiol® utilizes Precision Enzymatic Fermentation using non-GMO yeast strains (*Saccharomyces cerevisiae*). Our vertical supply chain ensures 100% molecular authenticity, avoiding high-heat evaporation to preserve the thiol groups required for clinical antioxidant activity.
4. Mechanism of Action
Glutathione reduced (GSH) functions as the primary donor for Glutathione Peroxidase (GPx). It facilitates the neutralization of reactive oxygen species (ROS) and acts as a central recycling agent for other antioxidants like Vitamin C and E, supporting systemic metabolic homeostasis.
5. Application Benefits
- Oxidation Defense: Functional property for hepatic detoxification support.
- Redox Equilibrium: May support the reduction of UV-induced oxidative dermal aging.
- Formulation Compatibility: Toluene-free profile ensures suitability for sensitive eye-care and sublingual products.
Advanced Engineering Systems
Sulfur Odor Suppression Engineering
We solve the “Formulation Rejection” risk. By removing trace volatile sulfur-containing impurities through multi-stage resin chromatography, we produce an Odor-Optimized Isolate suitable for gummies without heavy flavor masking.
Oxidation Resistance Packaging
GSH is prone to converting to GSSG in ambient air. Exbiol® utilize Nitrogen-Lock Processing and vacuum-sealed liners to keep GSSG levels <0.5% throughout the industrial shelf life.
6. Usage & Formulation Guide
Solubility: Highly water-soluble (50mg/ml). R&D Tip: Maintain formula pH below 4.5 to prevent auto-oxidation in aqueous systems. Processing: Avoid high-shear blending above 45°C to preserve molecular integrity.
7. Industrial Evolution
The industry has shifted from crude chemical synthesis to Precision Fermentation. Exbiol leads this shift by providing an isolate that is completely free of Toluene and Methanol, meeting the pharmaceutical “Green-API” standards of the EU and North American markets.
8. Pharma-Grade Analytical COA Matrix
8.1 Identity & Assay Profile
| Testing Item | Specification | Method | Standard |
|---|---|---|---|
| Assay (GSH) | 98.0% – 101.0% | HPLC-DAD | USP / EP |
| Specific Rotation | -15.5° to -17.5° | Polarimetry | USP <781> |
8.2 Elemental Impurities (ICP-MS)
| Item | Spec (mg/kg) | Method |
|---|---|---|
| Lead (Pb) | < 0.1 | ICP-MS |
| Arsenic (As) | < 0.1 | ICP-MS |
8.3 Safety & Residue Control
| Item | Spec (ppm) | Method |
|---|---|---|
| Residual Toluene | Non-Detected | GC-HS |
| Pesticide Residue | Negative | USP <561> |
8.4 Microbiological Standards
| Analysis | Specification | Method |
|---|---|---|
| Total Plate Count | < 500 cfu/g | USP <61> |
| Salmonella | Negative in 10g | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Packed in 25kg standard fiber drums with light-proof PE liners. Store at <20°C in a dry environment. GSH is moisture-sensitive; ensure nitrogen-sealed re-closure after sampling.
11. MOQ, Sample & Global Shipping
MOQ: 25kg bulk. 100g technical samples with full HPLC fingerprint available. Global dispatch from Shaanxi or Shanghai within 3-5 working days. DDP support.
12. Scientific Research & Clinical Data
Human trials demonstrate that oral L-Glutathione Reduced supports functional hepatic detoxification markers. Research confirms high bio-availability when administered via sublingual or acetylated delivery formats.
13. Applicable Industries
Nutraceuticals
Cosmeceuticals
14. B2B Application Scenarios
Industrial production of Skin-Brightening Capsules, Liver-Support Tinctures, and Anti-Aging NAD+ synergistic complexes. Optimized for high-volume automated softgel encapsulation.
15. Industrial Market Trends
Global demand is shifting toward Toluene-Free Glutathione as EU and US R&D giants move away from hydrocarbon-heavy solvents in line with “Clean Label” pharmaceutical trends.
16. Supplier Comparison & Procurement Guide
| Metric | Standard Trader Grade | Exbiol® Industrial Isolate |
|---|---|---|
| Odor Profile | Sulfur / Unrefined | Low-Odor Optimized |
| Solvent Control | Residual Toluene risk | Non-Detected (Toluene Free) |
| Traceability | Broker sourced | Direct Factory Fermentation |
17. Technical Procurement FAQ
How is the 99% assay of your Reduced Glutathione verified?
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Every batch is released via HPLC-DAD (High-Performance Liquid Chromatography) in accordance with USP monographs. We strictly verify the “Reduced” state (GSH) vs. the “Oxidized” state (GSSG), ensuring GSSG levels remain below 0.5% for maximum antioxidant potency.
Why is the Specific Optical Rotation critical for my R&D audit?
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The Specific Rotation (-15.5° to -17.5°) is the primary indicator of enantiomeric purity. It proves the material is the biologically active L-isomer, distinguishing our isolate from structurally identical but biologically inactive D-isomers often found in unrefined synthetic sources.
Can Exbiol provide raw spectral data such as 1H-NMR or FTIR?
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Yes. For Tier-1 pharmaceutical clients, we provide full FTIR Overlay Comparison and 1H-NMR spectra as part of the technical dossier. This confirms the molecular fingerprint and ensures zero adulteration.
How do you prevent the “Yellowing” of bulk Glutathione during sea freight?
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Yellowing is caused by auto-oxidation. We utilize Nitrogen-Blanketed Vacuum Sealing in double-layered UV-opaque PE liners. Our accelerated stability data (40°C/75% RH) confirms a >99% color retention over 180 days in industrial transit conditions.
Does your Glutathione comply with n-Hexane and Toluene residual limits?
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Our enzymatic fermentation process is Toluene-Free. We test for residual solvents via Headspace GC-MS following ICH Q3C guidelines. Both Toluene and n-Hexane are consistently Non-Detected (ND), ensuring the cleanest label for your final product.
What is the MOQ and lead time for a 5,000kg bulk order?
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Our standard MOQ is 25kg (one fiber drum). For 5,000kg bulk orders, our lead time is 3–5 working days from our Shaanxi central hub. We maintain an 18,000kg rolling buffer stock to ensure supply continuity for our OEM partners.
18. References & Regulatory Sources
- PubMed: Pharmacokinetics of Reduced Glutathione isomers.
- USP: Official Monograph for Glutathione API.
- FDA: GRAS Notice Database for Fermented Polypeptides.
Exbiol® Quality Assurance
Manufactured by Shaanxi Zhonghong Investment Technology Co., Ltd. 100% batch traceability. ISO 9001 & GMP Certified operations.
✔ Isomer Purity Verified
✔ 18,000kg Bulk Stock
