Azulene ≥99% CAS 275-51-4
EXBIOL® provides high-purity Azulene ≥99.0% by GC for analytical research, fine-chemical development and formulation evaluation. Procurement teams receive batch-specific commercial information, while R&D and QC teams can qualify identity, purity, impurity profile and physical constants before project approval.
| PRODUCT Azulene | ASSAY ≥99.0% GC | CAS NO. 275-51-4 | FORMULA C10H8 | MW 128.17 g/mol |
1. Procurement & R&D Dual-Track Supply
| For Sourcing & Procurement Confirm current batch purity, pack size, available quantity, lead time and logistics before commercial approval. Azulene should be sourced by exact CAS and assay rather than by the generic term “azulene derivative.” | For R&D & QC Qualification focuses on GC purity, NMR or IR identity, physical constants, impurity profile and batch documentation before analytical or formulation use. |
2. What Is Azulene?
Azulene is a non-benzenoid aromatic bicyclic hydrocarbon composed of fused five-membered and seven-membered rings. Its distinctive electronic structure gives the compound its intense blue-to-violet appearance.
3. Azulene vs. Guaiazulene — Do Not Mix the Two
| Parameter | Azulene | Guaiazulene |
|---|---|---|
| CAS No. | 275-51-4 | 489-84-9 |
| Formula | C10H8 | C15H18 |
| Molecular Weight | 128.17 | 198.30 |
| Chemical Position | Parent azulene hydrocarbon | Substituted azulene derivative |
| EXBIOL Page | This product | Separate product page |
4. Molecular & Registry Information
| CAS Registry Number | 275-51-4 |
| Molecular Formula | C10H8 |
| Molecular Weight | 128.17 g/mol |
| EC Number | 205-993-6 |
| MDL Number | MFCD00003810 |
| Chemical Class | Non-benzenoid aromatic hydrocarbon |
5. Commercial Technical Specification
| Parameter | EXBIOL® Target | Method |
|---|---|---|
| Azulene | ≥99.0% | GC |
| Identity | Conforms | ¹H NMR |
| IR Identity | Conforms | FT-IR |
| Melting Point | 98–103°C | Capillary Method |
| Water | ≤1.0% | Karl Fischer |
6. Physical Appearance & Thermal Profile
High-purity Azulene is a strongly colored crystalline solid. Commercial reference materials describe dark blue, blue-black, purple or very dark crystalline forms rather than a conventional white fine-chemical powder.
| Physical State | Solid |
| Appearance | Dark blue to blue-black crystalline powder / crystals |
| Melting Point | Approximately 98–103°C |
| Reference Boiling Point | Approximately 242°C |
7. GC Purity Verification
Gas chromatography is the preferred commercial purity method for high-purity Azulene and is widely used by established reference-material suppliers.
| Primary Assay Azulene ≥99.0% by GC. | Related Substances Evaluate total and individual chromatographic impurities. | Batch Evidence GC chromatogram available for qualification. |
8. NMR, IR & GC-MS Identity
Purity and identity answer different questions. GC quantifies the chromatographic purity, while ¹H NMR and FT-IR verify structural consistency. GC-MS can provide additional molecular-identity support for advanced projects.
¹H NMR spectrum of Azulene CAS 275-51-4 supporting structural identity confirmation. Quantitative purity is controlled separately by GC.
9. Representative COA Matrix
The following is a recommended release framework. Final results must come from the actual production batch.
| Test Item | Specification | Method |
|---|---|---|
| Identification | Conforms to reference | ¹H NMR |
| IR Identification | Conforms | FT-IR |
| Assay | ≥99.0% | GC |
| Melting Point | 98–103°C | Capillary |
| Water | ≤1.0% | Karl Fischer |
10. Impurity & Residual Solvent Control
| Control | Qualification Direction | Method |
|---|---|---|
| Total Related Substances | Within approved purity specification | GC |
| Single Unknown Impurity | Project-specific | GC |
| Residual Solvents | Per approved manufacturing process | HS-GC |
| Elemental Impurities | Project-specific | ICP-MS |
11. Solubility & Solution Evaluation
Azulene is not positioned as a water-soluble ingredient. Solubility and formulation compatibility should be evaluated in the customer’s actual solvent system.
12. Storage & Stability Control
High-purity Azulene should be protected from excessive heat and prolonged light exposure. Reference suppliers recommend storage in a cool, dark environment.
| Storage Environment | Cool and dark |
| Reference Temperature | Below approximately 15°C may be preferred for long-term handling |
| Container | Tightly sealed glass or compatible primary container |
| Final Requirement | Follow the batch-specific EXBIOL® TDS |
13. Manufacturing & Purification Control
High-purity Azulene should be qualified as a fine chemical rather than a crude botanical extract. Production control therefore centers on reaction or isolation chemistry, purification efficiency, chromatographic impurity control and structural verification.
The exact manufacturing route should be disclosed only according to the approved EXBIOL® production process and customer confidentiality requirements.
14. Application Positioning
| Analytical R&D Reference comparison, chromatographic development and structural research. | Fine-Chemical Development Intermediate, derivative and advanced materials research. | Formulation Evaluation Compatibility and feasibility projects subject to regulatory assessment. |
15. Cosmetic & Regulatory Safety Boundary
Azulene has historically appeared in cosmetic-use literature, but the Cosmetic Ingredient Review Expert Panel concluded that the available information was insufficient to support a safety conclusion for Azulene in cosmetic products.
16. Packaging, MOQ & Project Supply
Azulene ≥99% is a specialty fine chemical and should not be presented using a generic 25 kg botanical-extract packaging template. Commercial terms depend on purity, pack size, annual requirement and production schedule.
17. Technical Documentation Package
| Core Documents COA • Specification / TDS • SDS • GC Chromatogram • Manufacturing Summary • Batch Traceability | Advanced Qualification ¹H NMR • FT-IR • GC-MS • Residual Solvents • Elemental Impurities • Project-Specific Testing |
Regulatory Standard: In-house Standard. USP, EP or BP should not be claimed unless a formally applicable compendial monograph and batch release standard exist.
18. Buyer Qualification Checklist
| Buyer Question | Why It Matters | EXBIOL® Direction |
|---|---|---|
| Is the CAS exactly 275-51-4? | Prevents confusion with Guaiazulene. | CAS-specific qualification |
| How is purity measured? | Method affects comparability. | GC ≥99% |
| Is structural identity verified? | Purity alone does not prove identity. | NMR / IR support |
| Can I review a chromatogram? | Allows impurity-profile review. | Batch GC available |
| Is cosmetic use automatically approved? | Safety conclusions are market-specific. | No; regulatory review required |
19. Technical FAQ & Reference Context
Is Azulene CAS 275-51-4 the same as Guaiazulene?
No. Azulene is C10H8 with CAS 275-51-4, while Guaiazulene is C15H18 with CAS 489-84-9. They require separate specifications and technical documentation.
Why does EXBIOL use GC instead of HPLC for the main assay?
GC is widely used by established commercial Azulene suppliers for quantitative purity control and is appropriate for this high-purity aromatic fine chemical.
Can EXBIOL provide NMR or GC-MS data?
Advanced qualification can include ¹H NMR, FT-IR and GC-MS documentation according to project requirements and batch availability.
Can Azulene be marketed as a cosmetic soothing active?
Not automatically. Historical CIR review concluded that available data were insufficient to support a cosmetic safety conclusion for Azulene. Market-specific regulatory and safety review is required.
What documents are available for buyer qualification?
The technical package can include batch COA, specification, SDS, GC chromatogram and available identity documentation such as NMR, IR or GC-MS.
Reference context: PubChem CID 9231; NIST Chemistry WebBook; commercial GC and physical-property specifications from established analytical chemical suppliers; Cosmetic Ingredient Review safety assessment.
Qualifying Azulene CAS 275-51-4? Start With Identity and GC Purity.
Send your target purity, evaluation quantity, annual demand, destination market and intended application. EXBIOL® can prepare the appropriate analytical and commercial qualification package.
EXBIOL® • Phytochemical Technology Platform
Analytical Verification • Industrial Engineering • Regulatory Support
[email protected]
