High-purity Urolithin A raw material manufactured for global supplement brands, formulation companies, For formulation developers and global nutraceutical brands
1. What is Urolithin A?
Urolithin A (UA) is a natural metabolite produced from ellagitannins by the gut microbiota. It is the only postbiotic clinically shown to activate Mitophagy—the process of clearing dysfunctional mitochondria. Since 60% of the population lacks the specific gut flora to produce UA, Exbiol® provides a bio-identical, high-purity isolate that ensures predictable clinical outcomes for anti-aging and muscular endurance formulations.
2. Urolithin A Specification & Quality Parameters
Exbiol supplies high-purity Urolithin A raw material for global nutraceutical manufacturers, supplement brands, and research partners.
Each batch is verified through HPLC testing with complete quality documentation including COA, TDS, and MSDS.
| Parameter | Specification |
|---|---|
| Product Name | Urolithin A Powder / Urolithin A Bulk Ingredient |
| Active Content | Urolithin A ≥99.0% (HPLC Tested) |
| CAS Number | 1143-70-0 |
| Appearance | Light yellow to off-white crystalline powder |
| Purity Verification | 99% purity Urolithin A verified by HPLC analytical method |
| Particle Size | Standard: 80 Mesh / Micronized Grade: D90 <10μm |
| Melting Point | 340°C – 345°C |
| Loss on Drying | ≤1.0% |
| Quality Documentation | COA, TDS, MSDS, Batch Testing Report Available |
| Supply Capability | Bulk Urolithin A supply for international nutraceutical applications |
3. Urolithin A Manufacturing & Source
Exbiol® Urolithin A is produced under controlled pharmaceutical-grade manufacturing conditions to achieve a consistent molecular profile and high purity specification.
Our manufacturing process focuses on batch-to-batch consistency, impurity control, and analytical verification to meet global nutraceutical ingredient requirements.
4. Mechanism of Action
Urolithin A functions as a primary inducer of mitophagy. It crosses the cell membrane to activate the PINK1/Parkin-mediated pathway, which identifies and clears aged or damaged mitochondria. For R&D, UA is valued for its functional property of improving mitochondrial “fitness,” supporting ATP production efficiency and reducing the metabolic pro-oxidant load in muscle and neural tissues.
5. Application Benefits
Functional property for supporting healthy muscle fiber integrity and aerobic endurance.
May support the functional property of systemic mitochondrial autophagy (mitophagy).
6. Usage & Formulation Guide
- Solubility: Practically insoluble in water. We recommend micronized grade for capsules or liposomal delivery systems for liquid shots.
- pH Stability: Highly stable across pH 2.0 – 8.0, compatible with acidic fruit juice bases.
- Synergy: Combines exceptionally well with NAD+ precursors (NMN/NR) and Resveratrol for comprehensive anti-aging formulas.
7. Industrial Evolution
The market has evolved from raw pomegranate juice (unreliable UA conversion) to crude ellagic acid, and now to Exbiol’s Third-Generation Micronized Isolate. We utilize Jet-Milling Technology to reduce particle size to <10μm, significantly increasing the bioavailable surface area and overcoming the molecule’s inherent lipophilicity.
8. COA & Quality Control Specifications
8.1 Analytical Verification Package
Beyond standard COA documentation, Exbiol® provides advanced analytical verification for Urolithin A bulk ingredient qualification.
Each batch can be supported with analytical evidence including purity confirmation, molecular identity verification, and long-term stability evaluation.
- HPLC Purity Analysis:
Urolithin A purity verification with chromatographic fingerprint. - NMR Structural Identification:
Molecular structure confirmation through NMR spectrum analysis. - 24-Month Stability Study:
Long-term stability evaluation supporting shelf-life and product reliability. - Quality Documentation:
COA, TDS, MSDS and technical qualification documents available.
8.2 Heavy Metals (ICP-MS Verified)
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| Arsenic (As) | < 0.5 ppm | ICP-MS |
8.3 Pesticide Screen (Multi-Residue)
| Category | Spec | Method |
|---|---|---|
| Pesticides | Negative | GC-MS/MS |
| Solvent Residue | Ethanol < 500ppm | GC-Headspace |
8.4 Microbiological Standards
| Analysis | Spec | Method |
|---|---|---|
| Total Plate Count | < 1,000 cfu/g | USP <61> |
| Salmonella | Negative | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Primary: 1kg Al-foil bag; 25kg standard fiber drum with double-layered PE liners. Store at <25°C, humidity <60%. Shelf life: 36 months.
11. MOQ, Sample & Global Shipping
MOQ: 1kg trial batches. Samples: 10g-50g technical samples available with COA. Global air freight (FedEx/DHL) within 3-5 working days from our Shaanxi hub.
12. Clinical Data & Scientific Research
Human trials published in Nature Metabolism demonstrate that Urolithin A significantly increases muscle strength and aerobic endurance in aging cohorts by improving mitochondrial fitness. No medical treatment claims are implied.
13. Applicable Industries
Sports Nutraceauticals
Biohacking OEM
14. B2B Application Scenarios
Optimized for Contract Manufacturers (OEM/ODM) developing “NAD+ Booster” premium complexes, muscle recovery capsules, and high-purity longevity isolates.
15. Industrial Market Scenarios
For brands targeting the Healthy Aging segment on Amazon or Retail, choosing a 99% pure, micronized isolate is the primary differentiator for efficacy claims and passing transparency audits.
16. Supplier Comparison & Procurement Guide
Standard Industry Grade
- Raw Particle Size (Poor Bioavailability)
- Unverified Synthesis Catalysts
- Inconsistent Stock Availability
Exbiol® Micronized Grade
- Verified D90 < 10μm
- Methanol-Free Solvent System
- 3,000kg Bulk Stock Ready
17. Frequently Asked Questions About Urolithin A Bulk Supply
Q: What is the CAS number of Urolithin A?
The CAS number of Urolithin A is 1143-70-0.
Exbiol provides Urolithin A powder with documented specifications and analytical verification for global nutraceutical applications.
Q: What is Urolithin A raw material?
Urolithin A raw material is a high-value nutraceutical ingredient used by supplement manufacturers for cellular health and healthy aging formulations. Exbiol provides high-purity Urolithin A powder with professional documentation for global bulk applications.
Q: What purity of Urolithin A does Exbiol supply?
Exbiol supplies Urolithin A powder with ≥99% purity. Each batch is tested by HPLC analytical methods to verify active content and batch consistency.
Q: Do you provide COA and specification documents for Urolithin A?
Yes. We provide complete quality documentation including Urolithin A COA, TDS, MSDS, and batch testing reports to support customer qualification and regulatory review.
Q: Is Exbiol a Urolithin A manufacturer or trading supplier?
Exbiol is a professional ingredient manufacturer and supplier specializing in high-value phytochemicals and nutraceutical raw materials. We support bulk supply, technical documentation, and long-term cooperation with global customers.
Q: What packaging and bulk quantities are available for Urolithin A powder?
Urolithin A bulk powder can be supplied according to customer requirements. Standard packaging, technical specifications, and commercial quantities are available upon request.
Q: Can Exbiol provide customized Urolithin A solutions for supplement brands?
Yes. We support supplement companies, contract manufacturers, and R&D teams with customized specifications, documentation support, and bulk Urolithin A ingredient solutions.
18. References & Regulatory Sources
- PubMed: Urolithin A and Mitochondrial Health Study
- FDA: GRAS Notice (GRN) No. 791 (Urolithin A).
- Nature Metabolism: Clinical trials on muscular endurance.
Manufacturer & Quality Assurance
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified manufacturer specializing in high-purity longevity actives for pharmaceuticals and nutricosmetics.
✔ Molecular Identity Confirmed by NMR
✔ Micronized Grade Available (D90 <10μm)
✔ Complete Analytical Documentation Package
