Urolithin A Manufacturer | Bulk 98% 99% HPLC Powder | Wholesale Longevity Supply
1. What is Urolithin A?
Urolithin A (UA) is a natural metabolite produced from ellagitannins by the gut microbiota. It is the only postbiotic clinically shown to activate Mitophagy—the process of clearing dysfunctional mitochondria. Since 60% of the population lacks the specific gut flora to produce UA, Exbiol® provides a bio-identical, high-purity isolate that ensures predictable clinical outcomes for anti-aging and muscular endurance formulations.
2. Technical Specifications
| Parameter | Industrial Standard (HPLC) |
|---|---|
| Active Content | Urolithin A ≥ 98.0% / 99.0% |
| Melting Point | 340°C – 345°C |
| Particle Size | Standard: 80 Mesh / Micronized: D90 < 10μm |
| Loss on Drying | ≤ 1.0% |
3. Source & Manufacturing Origin
Exbiol® Urolithin A is produced via a specialized biomimetic synthesis process that replicates the natural metabolic conversion found in the gut. This ensures a 100% bio-identical molecular structure. Our production facility in Shaanxi utilizes pharmaceutical-grade precursors to ensure a non-GMO, zero-pesticide raw material base suitable for premium “Clean Label” applications.
4. Mechanism of Action
Urolithin A functions as a primary inducer of mitophagy. It crosses the cell membrane to activate the PINK1/Parkin-mediated pathway, which identifies and clears aged or damaged mitochondria. For R&D, UA is valued for its functional property of improving mitochondrial “fitness,” supporting ATP production efficiency and reducing the metabolic pro-oxidant load in muscle and neural tissues.
5. Application Benefits
Functional property for supporting healthy muscle fiber integrity and aerobic endurance.
May support the functional property of systemic mitochondrial autophagy (mitophagy).
6. Usage & Formulation Guide
- Solubility: Practically insoluble in water. We recommend micronized grade for capsules or liposomal delivery systems for liquid shots.
- pH Stability: Highly stable across pH 2.0 – 8.0, compatible with acidic fruit juice bases.
- Synergy: Combines exceptionally well with NAD+ precursors (NMN/NR) and Resveratrol for comprehensive anti-aging formulas.
7. Industrial Evolution
The market has evolved from raw pomegranate juice (unreliable UA conversion) to crude ellagic acid, and now to Exbiol’s Third-Generation Micronized Isolate. We utilize Jet-Milling Technology to reduce particle size to <10μm, significantly increasing the bioavailable surface area and overcoming the molecule’s inherent lipophilicity.
8. COA & Quality Control Specifications
8.1 Heavy Metals (ICP-MS Verified)
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| Arsenic (As) | < 0.5 ppm | ICP-MS |
8.2 Pesticide Screen (Multi-Residue)
| Category | Spec | Method |
|---|---|---|
| Pesticides | Negative | GC-MS/MS |
| Solvent Residue | Ethanol < 500ppm | GC-Headspace |
8.3 Microbiological Standards
| Analysis | Spec | Method |
|---|---|---|
| Total Plate Count | < 1,000 cfu/g | USP <61> |
| Salmonella | Negative | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Primary: 1kg Al-foil bag; 25kg standard fiber drum with double-layered PE liners. Store at <25°C, humidity <60%. Shelf life: 36 months.
11. MOQ, Sample & Global Shipping
MOQ: 1kg trial batches. Samples: 10g-50g technical samples available with COA. Global air freight (FedEx/DHL) within 3-5 working days from our Shaanxi hub.
12. Clinical Data & Scientific Research
Human trials published in Nature Metabolism demonstrate that Urolithin A significantly increases muscle strength and aerobic endurance in aging cohorts by improving mitochondrial fitness. No medical treatment claims are implied.
13. Applicable Industries
Sports Nutraceauticals
Biohacking OEM
14. B2B Application Scenarios
Optimized for Contract Manufacturers (OEM/ODM) developing “NAD+ Booster” premium complexes, muscle recovery capsules, and high-purity longevity isolates.
15. Industrial Market Scenarios
For brands targeting the Healthy Aging segment on Amazon or Retail, choosing a 99% pure, micronized isolate is the primary differentiator for efficacy claims and passing transparency audits.
16. Supplier Comparison & Procurement Guide
Standard Industry Grade
- Raw Particle Size (Poor Bioavailability)
- Unverified Synthesis Catalysts
- Inconsistent Stock Availability
Exbiol® Micronized Grade
- Verified D90 < 10μm
- Methanol-Free Solvent System
- 3,000kg Bulk Stock Ready
17. Technical FAQ for Bulk Buyers
Q: How does the purity of your Urolithin A compare to the Mitopure standard?
Every bulk batch strictly matches the high-purity isolate standard, with Urolithin A ≥ 98.0%. We provide a full 4-marker HPLC profile documenting zero residual synthesis catalysts and solvent compliance.
Q: Why is micronization critical for Urolithin A bulk powder?
Urolithin A is hydrophobic. Micronization to <10 microns increases effective surface area, significantly enhancing gastrointestinal dissolution and bioavailability compared to raw powder.
Q: Is your material GRAS compliant?
Yes, our Urolithin A is manufactured to meet Self-Affirmed GRAS status requirements for food and supplement safety in the USA.
Q: What is the lead time for 1,000kg?
Standard dispatch is 3-5 working days from our central hub.
Q: Is your Urolithin A Non-GMO?
Yes, all precursors and solvents used are verified Non-GMO.
Q: Do you offer liposomal Urolithin A liquid?
Yes, we can provide customized nano-emulsion or liposomal grades for high-potency liquid energy shots.
18. References & Regulatory Sources
- PubMed: Urolithin A and Mitochondrial Health Study
- FDA: GRAS Notice (GRN) No. 791 (Urolithin A).
- Nature Metabolism: Clinical trials on muscular endurance.
Manufacturer & Quality Assurance
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified manufacturer specializing in high-purity longevity actives for pharmaceuticals and nutricosmetics.
✔ Micronized D90 < 10μm Ready
✔ 3,000kg Bulk Stock Ready
✔ Full Batch Traceability & Dossiers
