TECA Manufacturer | Bulk Centella Asiatica Extract 95% | Wholesale Titrated Isolate
1. What is TECA?
TECA is a highly purified, titrated active ingredient derived from Centella asiatica. Unlike crude extracts, TECA is a defined isolate standardized to ≥95% triterpenes. It is engineered to stimulate collagen synthesis and epidermal barrier restoration. Exbiol® TECA is purified through multistage column chromatography to ensure the removal of plant pigments, yielding a clean, off-white crystalline powder for professional formulations.
2. Technical Specifications
| Parameter | Industrial Standard (HPLC) |
|---|---|
| Total Triterpenes | ≥ 95.0% |
| Asiaticoside Content | 36.0% – 44.0% |
| Genins (Asiatic + Madecassic) | 54.0% – 66.0% |
| Appearance | Off-white Crystalline Powder |
3. Source & Biological Origin
We source authentic Centella asiatica (L.) Urb. from GAP-compliant wetlands. We strictly select aerial parts where triterpene density peaks. Every lot undergoes DNA barcoding to verify species authenticity, ensuring the 4-marker molecular integrity required for dermaceutical grade TECA.
4. Mechanism of Action
TECA functions by stimulating TGF-β signaling pathways within human dermal fibroblasts. It acts as a biological catalyst for Type I and III collagen synthesis. Furthermore, it inhibits matrix metalloproteinases (MMPs), effectively protecting the skin’s extracellular matrix from degradative stress.
5. Application Benefits
Functional property for accelerating basement membrane zone (BMZ) restoration.
May support functional property of reducing post-procedure redness.
6. Usage & Formulation Guide
- Solubility: Lipophilic. Dissolve in 1:15 ratio with Propylene Glycol or Ethanol.
- Stability: Maintains molecular integrity between pH 4.5 – 7.5.
- Thermal Care: Add during the cooling phase (<50°C) to maintain marker stability.
7. Industrial Evolution
The market has evolved from 10:1 extracts to the modern Titrated Isolate (TECA). Exbiol® utilizes third-generation purification technology—Chromatographic Isomer Separation—providing a pharmaceutical-grade off-white active free from brown chlorophyll interference.
8. COA & Quality Control Specifications
8.1 Heavy Metals (ICP-MS Verified)
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| Arsenic (As) | < 0.5 ppm | ICP-MS |
8.2 Pesticide Screen (Multi-Residue)
| Category | Spec | Method |
|---|---|---|
| Total Pesticides | < 0.01 mg/kg | GC-MS/MS |
| Organochlorines | Negative | USP <561> |
8.3 Microbiological Standards
| Analysis | Spec | Method |
|---|---|---|
| Total Plate Count | < 100 cfu/g | USP <61> |
| Pathogenic Bacteria | Negative | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Primary: 1kg Al-foil bag; 25kg standard fiber drum. Store at <25°C in a dry place. Shelf life: 24 months sealed.
11. MOQ, Sample & Global Shipping
MOQ: 1kg for trials. Samples: 10g فنی technical samples with HPLC fingerprints. Global air dispatch within 3 working days from Shaanxi hub.
12. Clinical Data & Scientific Research
Clinical trials on 0.5% TECA demonstrate a 30% increase in dermal hydroxyproline levels over 8 weeks, indicating functional property support for collagen architecture. In-vivo tests show TECA accelerates barrier recovery 40% faster than standard placebo.
13. Applicable Industries
Dermaceuticals
Wound Healing OEM
14. B2B Application Scenarios
Optimized for Contract Manufacturers (OEM/ODM) developing “Cica-creams,” post-laser serums, and clinical-grade barrier repair lotions requiring genin:glycoside precision.
15. Industrial Market Scenarios
For brands targeting the Medical Grade Aesthetic market, Exbiol® TECA provides the verified molecular consistency needed for sensitive skin safety audits in the EU and USA.
16. Supplier Comparison & Procurement Guide
- Variable Genin:Glycoside Ratio
- Methanol Residual Risks
- Brown Pigment Interference
- Fixed 4-Marker Titration (40:60)
- 100% Ethanol/Water Only
- Off-white Crystal (Pigment-Free)
17. Technical FAQ for Bulk Buyers
Q: How does the marker ratio of your TECA compare to the USP monograph?
Every batch matches the USP Centella standard ratio for Titrated Extracts: Asiaticoside (approx. 40%) and Genins (approx. 60%). We provide full HPLC chromatograms for every industrial lot.
Q: Is your TECA 100% water-soluble?
No, pharmaceutical-grade TECA is lipophilic. For aqueous drink or serum formulations, we recommend pre-dissolving in BG or utilizing our Nano-TECA CWD grade.
Q: What is the lead time for 1,000kg?
Standard dispatch is 3-5 working days from our central Shaanxi hub.
Q: Do you use Methanol for genin separation?
No. Exbiol® uses 100% Ethanol/Water dual-solvent systems to comply with clean-beauty standards.
Q: Is your TECA non-GMO certified?
Yes, our Centella Asiatica is non-genetically modified and grown without prohibited pesticides.
Q: Can I get a full batch fingerprint with the technical sample?
Yes, we provide the HPLC fingerprint profile with every sample to verify the four triterpene markers.
18. References & Regulatory Sources
- PubMed: Asiaticoside and Collagen stimulation.
- FDA: GRAS Ingredient Database for Botanical Extracts.
- USP-NF: Monograph for Centella Asiatica Titrated Extract.
- ISO 9001:2015 Manufacturing Quality Standards.
Manufacturer & Quality Assurance
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified manufacturer specializing in high-purity titrated botanical isolates.
✔ Batch Traceability & Full Dossiers
✔ Methanol-Free Solvent Control
✔ 10,000kg Bulk Stock Ready
