Guaiazulene ≥99.9% by GC
Batch-qualified Guaiazulene CAS 489-84-9 with 99.92% GC purity, UV identity verification and technical documentation for cosmetic formulation and analytical R&D.
| ≥99.9% GC | CAS 489-84-9 | INCI GUAIAZULENE | Batch GU-260601 |
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1. Procurement & R&D Dual-Track Qualification
For Procurement Commercial QualificationBatch GU-260601 provides 300 kg documented quantity, 99.92% GC purity and batch-specific analytical results. Commercial supply, packaging configuration, MOQ and delivery schedule are confirmed against current batch availability. | For R&D / QA Analytical QualificationQualification focuses on GC purity, UV identity, phase behavior, water content, inorganic residue, heavy metals and formulation-relevant solubility. |
2. What Is Guaiazulene?
Guaiazulene is a deep-blue azulene derivative identified by CAS No. 489-84-9 and molecular formula C15H18. It is a distinct chemical substance rather than a generic “azulene extract.”
For EXBIOL qualification, the material is controlled as a defined high-purity molecule with GC as the primary quantitative purity method and UV-Vis as an additional identity control.
3. Guaiazulene vs. Azulene — Do Not Confuse the Two
| Parameter | Guaiazulene | Azulene |
|---|---|---|
| CAS No. | 489-84-9 | 275-51-4 |
| Formula | C15H18 | C10H8 |
| Molecular Weight | 198.30 g/mol | 128.17 g/mol |
| EXBIOL Positioning | Premium cosmetic ingredient / formulation R&D | Fine chemical / analytical R&D |
4. Molecular & Registry Information
| Product | Guaiazulene |
| INCI | GUAIAZULENE |
| CAS | 489-84-9 |
| EC | 207-701-2 |
| Molecular Formula | C15H18 |
| Molecular Weight | 198.30 g/mol |
5. Batch GU-260601 — Technical Specification
| Testing Item | Specification | Batch Result | Method |
|---|---|---|---|
| Appearance | Dark blue liquid or crystalline solid | Conforms | Visual |
| Identification | UV λmax 604–608 nm | Conforms | UV-Vis |
| Purity | ≥99.9% | 99.92% | GC (Internal) |
| Congealing Temperature | ≥30.0°C | 30.3°C | USP <651> |
| Water Content | ≤0.1% | 0.02% | Karl Fischer |
| Residue on Ignition | ≤0.1% | 0.04% | USP <281> |
6. Appearance & Temperature-Dependent Phase Behavior
Guaiazulene is qualified as a dark blue material that may appear as a crystalline solid or as a liquid depending on temperature and handling history.
The current batch shows a congealing temperature of 30.3°C. Accordingly, differences in physical form during storage or transport near this transition temperature should not automatically be interpreted as a quality failure.
Buyer note: visual appearance should be evaluated together with GC purity, UV identity and batch storage history.
7. UV-Vis Identity Verification
Batch GU-260601 conforms to the specified UV-Vis maximum-absorbance window. UV identity is used as an orthogonal identity check alongside chromatographic purity control.
8. GC Purity Verification
Gas chromatography is the primary quantitative purity method for this Guaiazulene grade.
GC purity and UV identity answer different qualification questions: GC quantifies chromatographic purity, while UV-Vis supports identity verification.
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📑 Batch COA & GC Review GU-260601 purity and batch-specific QC results. | 💡 Evaluation Sample Request an evaluation quantity from the applicable batch. | 🏭 Commercial Supply Confirm quantity, packaging, lead time and project pricing. | 🔬 Regulatory Dossier Request ISO 16128 and source-origin documentation where applicable. |
9. Heavy Metal Control — Batch Results
| Element | Current Specification | GU-260601 Result | Method |
|---|---|---|---|
| Lead (Pb) | ≤10 ppm | <1.5 ppm | ICP-MS |
| Arsenic (As) | ≤2 ppm | <0.01 ppm | ICP-MS |
| Cadmium (Cd) | ≤5 ppm | <0.18 ppm | ICP-MS |
| Mercury (Hg) | ≤1 ppm | <0.002 ppm | ICP-MS |
| Nickel (Ni) | ≤20 ppm | <1 ppm | ICP-MS |
| Antimony (Sb) | ≤100 ppm | <5 ppm | ICP-MS |
Buyer-specific tighter elemental limits can be evaluated separately against manufacturing capability and current batch data.
10. Microbiological Control
| Test | Specification | Result | Method |
|---|---|---|---|
| Total Plate Count | ≤100 cfu/g | <10 cfu/g | USP <61> |
| Yeast & Mold | ≤10 cfu/g | Not Detected | USP <61> |
| Pathogens | Negative | Negative | USP <62> |
11. Solubility & Formulation Integration
| Compatible Media Soluble in fatty oils, ethanol and mineral oils according to the current technical declaration. | Water Phase Insoluble in water. Direct addition to an aqueous phase without an appropriate solubilization or delivery strategy is not recommended. |
12. Source & Manufacturing Route
Declared source feedstock: Guaiac wood oil.
Purification direction: Controlled processing followed by final recrystallization for high-purity Guaiazulene.
The exact manufacturing-route description, botanical feedstock identity and natural-origin calculation should be matched to the applicable manufacturing declaration before customer regulatory submission.
13. ISO 16128 Natural-Origin Documentation
The current dossier declares a Natural Origin Index of 1.0 under ISO 16128. For customer qualification, this statement should be supported by the applicable manufacturer calculation and source-traceability documentation.
14. Storage & Oxidation Control
| Recommended Storage | 2–8°C |
| Light Exposure | Protect from direct light |
| Container | Keep tightly sealed |
| Headspace | Nitrogen protection where applicable |
| Shelf Life | 24 months under specified storage conditions |
Temperature, oxygen and light exposure should be controlled to minimize oxidation and unwanted color change during storage.
15. Purity, Moisture & Inorganic Residue Control
99.92% GC PURITY | 0.02% WATER | 0.04% RESIDUE ON IGNITION |
16. Application Positioning
EXBIOL positions this Guaiazulene grade for technical qualification in:
- Premium cosmetic formulation development
- Oil-phase and solvent-based formulation systems
- Cosmetic ingredient benchmarking and raw-material qualification
- Analytical R&D and reference-comparison projects
- Project-specific formulation and stability evaluation
17. Regulatory & Compliance Boundary
| Item | Current Position |
|---|---|
| INCI | GUAIAZULENE |
| Product Standard | In-house / Enterprise Standard |
| USP Methods | Selected USP general methods are used for specific tests; this does not make the product USP grade. |
| Declarations | Vegan / Non-GMO / BSE-TSE Free / Cruelty-Free subject to applicable signed declaration. |
| Finished Product Compliance | Customer is responsible for market-specific formulation, safety and finished-product regulatory assessment. |
18. Documentation & Project Supply
Technical Package
| Project Supply
|
19. Technical FAQ
Is Guaiazulene CAS 489-84-9 the same as Azulene CAS 275-51-4?
No. They are different chemical substances with different CAS numbers, molecular formulas, molecular weights and qualification specifications.
Why can Guaiazulene appear as either a solid or liquid?
The current batch has a congealing temperature of 30.3°C, so physical form can change with temperature. Identity and quality should be confirmed using analytical data rather than appearance alone.
How is purity tested?
The primary quantitative purity method is gas chromatography. Batch GU-260601 reports 99.92% GC purity against a ≥99.9% specification.
Is Guaiazulene water soluble?
No water solubility is claimed. The current technical declaration states solubility in fatty oils, ethanol and mineral oils and insolubility in water.
Is this product USP grade?
No. The material is controlled under an in-house standard. Selected USP general test methods are used for individual quality attributes.
Can EXBIOL support qualification before commercial purchase?
Yes. Batch documentation, analytical data and evaluation quantities can be reviewed as part of a project-specific technical qualification process.
20. References & Regulatory Context
The following independent sources are provided to support chemical identity, regulatory context and scientific background. They do not replace the batch-specific EXBIOL Certificate of Analysis, Safety Data Sheet, customer safety assessment or market-specific regulatory review.
The U.S. FDA lists Guaiazulene (CAS 489-84-9) as a permanently listed color additive exempt from certification for use in externally applied cosmetics, subject to the applicable requirements of 21 CFR §73.2180.
Wang L, Yan J, Fu PP, Parekh KA, Yu H. Photomutagenicity of cosmetic ingredient chemicals azulene and guaiazulene. Mutat Res. 2003;530(1-2):19-26. PMID: 14563527.
A peer-reviewed review discusses the chemistry, physicochemical properties and experimental biological research associated with azulene derivatives, including guaiazulene. PMID: 33551629.
External references are provided solely for ingredient identity, scientific background and regulatory-context purposes. Published experimental findings do not establish that EXBIOL® Guaiazulene prevents, treats or cures any disease, nor do they substantiate therapeutic claims for cosmetic finished products. FDA listing of Guaiazulene for permitted color-additive use does not constitute approval of every formulation, concentration, intended use or finished product. Customers are responsible for confirming applicable formulation safety, permitted use levels, labeling and regulatory requirements in each target market. Batch-specific quality claims are supported only by the applicable EXBIOL batch documentation.
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