Glabridin Manufacturer | Bulk 40% 90% HPLC Powder | Wholesale Technical Supply
1. What is Glabridin?
Glabridin (CAS 59870-68-7) is a high-potency prenylated isoflavonoid derived from Glycyrrhiza glabra root. Often termed “Whitening Gold,” it is the most efficient natural tyrosinase inhibitor known to science. Unlike crude licorice extracts, Exbiol® Glabridin is an engineered isolate, purified to ensure maximum biological potency and minimal color interference in final emulsions.
2. Technical Specifications
| Parameter | Industrial Standard |
|---|---|
| Active Content | Glabridin 40% / 90% / 98% (HPLC) |
| Specific Rotation | +22.0° to +28.0° |
| Appearance | Off-white to White Powder |
| Loss on Drying | ≤ 1.0% |
3. Source & Biological Origin
We source authentic Glycyrrhiza glabra from our GAP-compliant cultivation base. We strictly utilize 3-year-old roots to maximize Glabridin accumulation and perform DNA barcoding on every lot to eliminate common adulteration with non-active species.
4. Mechanism of Action
Glabridin functions as a competitive inhibitor of tyrosinase. It binds to the enzyme’s active site with 15x higher affinity than Kojic acid. Additionally, it inhibits ROS production and COX-2 activity, making it a dual-action active for both brightening and soothing.
5. Application Benefits
Functional property 232x more effective than Hydroquinone in cellular tests.
May support functional property of reducing erythema post-UV exposure.
6. Usage & Formulation Guide
- Solubility: Lipophilic. Dissolve in 1:10 ratio with Ethanol or Butylene Glycol.
- Stability: Critical pH range 3.5 – 7.5. Avoid highly alkaline environments.
- Thermal Care: Add during the cooling phase (<45°C) to prevent auto-oxidation.
7. Industrial Evolution
The industry has moved from crude powders to Exbiol’s Third-Generation Isomer-verified Isolates. We utilize multistage column chromatography to remove Glycyrrhizic acid and root pigments, providing a “crystal-clean” active for the luxury dermaceutical market.
8. COA & Quality Control Specifications
8.1 Heavy Metals (ICP-MS Verified)
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 1.0 ppm | ICP-MS |
| Mercury (Hg) | < 0.1 ppm | ICP-MS |
8.2 Pesticide Screen (Multi-Residue)
| Category | Spec | Method |
|---|---|---|
| Organophosphorus | Negative | GC-MS/MS |
| Total Pesticides | < 0.01 mg/kg | USP <561> |
8.3 Microbiological Standards
| Analysis | Spec | Method |
|---|---|---|
| Total Plate Count | < 100 cfu/g | USP <61> |
| Pathogenic Bacteria | Negative | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Primary: 1kg Al-foil bag; 25kg standard fiber drum. Store at <20°C in a dry, dark place to prevent UV-induced degradation. Shelf life: 24 months.
11. MOQ, Sample & Global Shipping
MOQ: 1kg for trial orders. Samples: 10g technical samples available with COA. Global air freight dispatch within 3-5 working days from Shaanxi hub.
12. Clinical Data & Scientific Research
In-vitro research confirms Glabridin’s ability to inhibit PGE2 production, indicating a significant functional property in modulating inflammatory markers. Human patch tests (at 0.1%) show zero irritancy, validating its status as a “Safe-Skin-Brightener.”
13. Applicable Industries
Luxury Skincare
OTC Topicals
14. B2B Application Scenarios
Specifically engineered for Contract Manufacturers (OEM/ODM) developing “Clean-Beauty” brightening serums and high-efficacy anti-spot night creams.
15. Industrial Market Scenarios
For brands targeting the Pregnancy-Safe Brightening market, Glabridin provides the ideal marketing story backed by robust clinical safety data.
16. Supplier Comparison & Procurement Guide
Standard Industry Grade
- High Color Interference
- Unverified Isomer Ratio
- Inconsistent Solubility
Exbiol® HPLC Grade
- Verified Specific Rotation
- Low Color Profile
- Full Batch Fingerprinting
17. Technical FAQ for Bulk Buyers
Q: How does the fatty acid ratio of your CO2 oil compare to the USP monograph?
While Glabridin is an isoflavonoid, we verify its profile against USP botanical standards. Our 90% grade contains strictly controlled markers, ensuring 1:1 biological equivalence to official research material.
Q: Why is your 40% Glabridin off-white instead of brown?
Brown color signifies residual tannins and pigments. Our purification removes these, preventing browning in your final cosmetic cream.
Q: Is your material water-soluble?
No, it is lipophilic. We recommend solvent carriers like PG or Butylene Glycol for incorporation into water-based serums.
Q: What is the lead time for 500kg?
Standard dispatch is 3-5 working days from our central Shaanxi hub.
Q: Is it non-GMO certified?
Yes, every batch is verified non-GMO and cultivated without prohibited pesticides.
Q: Does it contain Glycyrrhizic Acid?
We control glycyrrhizic acid <0.5% to ensure the extract does not interfere with emulsion viscosity or cause irritation.
18. References & Regulatory Sources
- PubMed: Pharmacological Activity of Glabridin
- FDA: GRAS Ingredient Database for Botanical Actives.
- USP: NF Monographs for Licorice Root Extracts.
- Cosmetic Ingredient Review (CIR) Safety Data.
Manufacturer & Quality Assurance
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified manufacturer specializing in high-purity botanical extracts for dermaceuticals and pharmaceuticals.
✔ 90%-98% HPLC Verification
✔ Batch Traceability & Full Dossiers
✔ 5,000kg Ready-to-Ship Stock
