Premium EGCG Monomer Manufacturer: The Gold Standard for Pharmaceutical Formulation
Maintain zero production downtime. We hold 5,500kg ready-stock for 3-5 day dispatch. Standard 25kg drums optimized for high-volume automated lines.
Secure your formula stability with 36-month real-time stability data. Verified Caffeine N.D. via LX-8 technology. 1H-NMR identity verified.
989-51-5
99.1% — 99.7%
Not Detected
0.86 g/ml
36 Months
USP / EP / JP
1. What is EGCG Monomer?
EGCG (Epigallocatechin Gallate) is the primary bioactive catechin in green tea. In its monomer isolate form, it represents the pinnacle of phytochemical purification. Unlike generic extracts, Exbiol® provides a crystalline active optimized for high molecular redundancy, ensuring clinical-grade dosages in compact delivery systems with zero stimulant side effects.
2. Technical Specifications
Pure white crystalline powder. Particle size optimized for sachet and capsule dispersion. Solvent system strictly Ethanol/Water only.
3. Source & Origin
Sourced from high-ORAC Camellia sinensis leaves from GAP-compliant mountain plantations. We utilize a 100% transparent “Farm-to-Batch” traceability protocol, meeting the strict audit requirements of the Swire Group (Finlays) tier.
4. Mechanism of Action
EGCG acts as a biological modulator of Sirtuin-1 and a direct scavenger of mitochondrial reactive oxygen species (ROS). It inhibits Catechol-O-methyltransferase (COMT), supporting the functional property of sustained fat oxidation and cardiovascular cellular protection.
5. Application Benefits
- Metabolic Performance: Functional property for supports calorie expenditure.
- Mitochondrial Support: Functional active in cellular longevity complexes.
- Water-Clear Solubility: Formulation advantage for premium RTD clear drinks.
6. Usage & Formulation Engineering Guide
Browning Prevention: Maintain final formulation at pH 3.0 — 4.5. EGCG is sensitive to auto-oxidation in alkaline environments.
Processing: Add during the “Cooling Stage” (<45°C) in industrial emulsions to prevent thermal isomerization.
7. Industrial Evolution
The industry has moved from 50% polyphenols to Exbiol’s **Third-Generation Molecular Isolate**. We utilize LX-8 Selective Adsorption to isolate EGCG at 99.7% purity, ensuring zero caffeine noise in night-time longevity formulas.
8. Pharma-Grade Analytical COA Matrix
8.1 Identity & Assay Profile
| Item | Industrial Specification | Test Method |
|---|---|---|
| Assay (EGCG) | ≥ 99.0% | HPLC-DAD |
| Specific Rotation | -165.0° to -180.0° | USP <781> |
8.2 Elemental Impurities (ICP-MS)
| Item | Standard | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| Arsenic (As) | < 0.5 ppm | ICP-MS |
8.3 Safety & Residue Control
| Item | Spec | Method |
|---|---|---|
| Caffeine | Not Detected | HPLC |
| Residual Ethanol | < 50 ppm | GC-HS |
9. Manufacturing Process
Leaf Extraction → LX-8 Resin Capture → RO Cold Enrichment → Fractional Recrystallization → Vacuum Drying (12h+) → Sifting → Nitrogen Sealing.
10. Storage & Packaging
Packed in 25kg standard fiber drums with light-proof PE liners. Store below 25°C. Shelf life: 36 months verified.
11. MOQ & Shipping
MOQ: 25kg bulk. 50g trial samples available. Global air/sea dispatch within 3-5 days. DDP support.
12. Scientific Research
36-month real-time stability data confirms active retention ≥ 99.8%. PubMed clinical research confirms its role in supporting metabolic energy flux.
13. Applicable Industries
Nutraceuticals
Cosmeceuticals
15. Buyer Qualification Guide: Auditing EGCG Suppliers
Audit Checklist for Sourcing Giants:
- Does the supplier provide 1H-NMR Identity Verification?
- Is the Caffeine status verified at N.D. (Not Detected) level via HPLC?
- Are there real-time 36-month stability charts available?
16. Supplier Comparison
| Metric | Standard Industry | Exbiol® EGCG |
|---|---|---|
| Color Stability | Browning in 6 months | 36 Months Clear |
| Solvent Profile | Variable residues | Verified ≤ 50 ppm |
17. Technical FAQ (Industrial Decision Center)
How is the 99% assay verified specifically for EGCG isomers? (Ref: Section 04)
Every batch is released via HPLC-DAD against our primary Trans-EGCG reference standard. This ensures the isolate is free from epimerization or degradation byproducts common in generic green tea extracts.
Can you provide raw NMR data for our R&D audit? (Ref: Section 05)
Yes. For pharmaceutical-tier clients, we provide full 1H-NMR spectra as part of our Technical Qualification Package to confirm absolute molecular identity and chiral purity.
How do you prevent browning in long-term storage? (Ref: Section 11)
We utilize RO Cold Enrichment and nitrogen-blanketed vacuum sealing. Our real-time 36-month stability data confirms <0.2% color shift, a critical requirement for high-end cosmetic serums.
Is your EGCG dossier ready for European EFSA audits? (Ref: Section 12)
Absolutely. Our dossier includes full pesticide screens (EU 396/2005) and residual solvent analysis (ICH Q3C), ensuring zero-risk customs clearance in the EU and North America.
What is the lead time for a 5,000kg bulk order? (Ref: Section 14)
We maintain a 5,500kg rolling buffer stock. Standard lead time is 3-5 working days from our Shaanxi hub to global air/sea ports. Small R&D samples (50g) dispatch within 24 hours.
18. References
PubMed: EGCG bio-availability in human myocytes. | USP: Official Monograph for Epigallocatechin Gallate. | ISO 22000 quality systems.
Exbiol® Quality Assurance & Certification
“We don’t just supply ingredients; we provide molecular certainty.” — Liao Daohai, Q.C. Director. Manufactured in our USP-audited facility with 100% batch traceability.
✔ 36-Month Stability Validated
✔ 5,500kg Bulk Stock
