● MOQ: 25kg / 1kg Sample
● Lead Time: 3-5 Working Days
● Inventory: 8,500kg Ready-Stock
● Source: 100% Fruiting Body
29-Year Phyto-Chemical Authority
Dual-Standardized • Starch-Free • DNA Authenticated
Lion’s Mane Extract Manufacturer | Bulk Hericenones 3% | Wholesale High-Purity Supply
Sourcing Solutions
Eliminate supply chain instability with Exbiol® global inventory. 8,500kg ready-to-ship. 3-5 day dispatch. Standard 25kg drums optimized for automated capsule lines.
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R&D Support
Validate your neuro-formula with HPLC Fingerprinting. Verified Hericenones ≥3.0% and (1,3/1,6)-β-D-Glucan ≥25.0%. Megazyme® verified starch-free isolate.
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CAS: 483-35-2 (Hericenone A)
ASSAY: Hericenones ≥ 3%
GLUCAN: Beta-Glucan ≥ 25%
STOCK: 8,500kg+
CERT: DNA Authenticated
✔ 100% Batch Traceability✔ Megazyme® Enzyme Verification✔ Starch-Free (Alpha-Glucan < 1%)✔ Global DDP Logistics
Technical Investigation & Procurement Hub
Industrial Engineering Dashboard
Active Marker
Hericenones A+C+D ≥ 3.0%
Assay (Beta-Glucan)
≥ 25.0% (Megazyme)
Alpha-Glucan (Starch)
≤ 1.0% (Starch-Free)
Extraction Source
100% Fruiting Body
Tap Density
0.45 – 0.65 g/ml
Compliance
GMP / ISO 22000
1. What is Lion’s Mane Extract (Hericium erinaceus)?
Lion’s Mane Extract is a high-value functional mushroom active derived from the fruiting bodies of Hericium erinaceus. Industrially, it is classified by its unique concentration of **Hericenones**, small molecules capable of crossing the blood-brain barrier. At Exbiol®, our extract is engineered via multi-stage temperature-controlled water extraction to preserve the (1,3)/(1,6)-β-D-Glucan structural integrity while ensuring the total removal of starch-based fillers (Alpha-glucans), making it the gold-standard active for cognitive health and neuro-protection formulations.
2. Technical Specifications
Standardized Phyto-monograph grade. DNA-authenticated fruiting body origin. Verified Starch-free profile.
3. Source & Origin
Our Hericium erinaceus is wild-simulated and cultivated in GAP-compliant mountain wood logs. Unlike common industrial mycelium grown on grain (which contains up to 60% starch), Exbiol strictly utilizes **100% Fruiting Bodies**. Every lot is DNA-sequenced to verify species identity, ensuring the synergistic presence of hericenones that are absent in lab-grown mycelial alternatives.
4. Mechanism of Action
The molecular efficacy of Lion’s Mane is driven by the stimulation of **Nerve Growth Factor (NGF) synthesis** in the brain. Hericenones act as low-molecular-weight ligands that cross the blood-brain barrier to trigger fibroblast activity. Furthermore, the (1,3/1,6)-β-D-Glucans provide a functional property of modulating the gut-brain axis through the Dectin-1 receptors on intestinal immune cells.
5. Application Benefits
- Cognitive Support: Functional property for supporting healthy NGF levels.
- Neuro-Plasticity: May support the functional property of myelin sheath integrity.
- Gut-Brain Axis: Functional active in supporting intestinal mucosal immunity.
Advanced Engineering Systems
Alpha-Glucan Purification
Industrial challenge: Grain-grown mycelium hides fillers. Exbiol® utilizes **Enzymatic Separation** to ensure Alpha-Glucan (Starch) levels are < 1.0%. This provides 2.5x more active beta-glucans per dose than standard market extracts.
Flowability Enhancement
We solve the “Sticky Powder” challenge. By strictly controlling the **Tapped Density at 0.55 g/ml**, we ensure high-speed automated line compatibility with zero clogging in capsule-filling machines.
Crystal Stability Engineering
Our spray-drying process utilizes low-temperature parameters to prevent the Caramelization Risk of mushroom sugars, preserving the off-white color and bitter-sweet sensory profile.
6. Usage & Formulation Guide
Solubility: Partially water-soluble. For liquid shots, high-shear mixing is required. R&D Recommendation: Synergizes with Bacopa Monnieri and Huperzine-A. pH Stability: Highly stable across pH 3.0 – 7.5. Compatible with Pectin-based gummy systems.
7. Industrial Evolution
The market has shifted from crude dried mushroom powder to mycelium-on-grain, and finally to Exbiol’s **Fourth-Generation Fruiting Body Isolate**. By focusing on hericenone titration (3%) rather than simple ratios (10:1), we ensure batch-to-batch neuro-efficacy.
Technical Evidence & Batch Performance
HPLC Fingerprint
[Illustrative Engineering Simulation] Documenting 3.12% Hericenones A+C+D. Verified absence of maltodextrin dilution spikes.
Megazyme® Verified Glucan
Total Beta-Glucan verified ≥ 25.0% using the official AOAC dual-enzymatic methodology.
8. Pharma-Grade Analytical COA Matrix
8.1 Identity & Assay Profile
| Testing Item | Industrial Specification | Test Method |
|---|
| Hericenones A+C+D | ≥ 3.0% | HPLC-DAD |
| (1,3/1,6)-β-D-Glucan | ≥ 25.0% | Megazyme Enzymatic |
| Alpha-Glucan (Starch) | ≤ 1.0% | Iodine Colorimetric |
8.2 Heavy Metals (Trace Analysis)
| Item | Spec (mg/kg) | Method |
|---|
| Lead (Pb) | < 0.5 | ICP-MS |
| Arsenic (As) | < 0.5 | ICP-MS |
| Mercury (Hg) | < 0.1 | ICP-MS |
8.3 Safety & Residue Control
| Item | Spec | Method |
|---|
| Pesticide Residues | Negative | GC-MS/MS |
| Residual Solvents | Ethanol Only | GC-HS |
8.4 Microbiological Profile
| Analysis | Spec | Method |
|---|
| Total Plate Count | < 450 cfu/g | USP <61> |
| Salmonella | Negative | USP <62> |
9. Manufacturing Flow Description
Log-Cultivated Fruiting Bodies → Crushing → Dual-Temp Aqueous Extraction → Centrifugal Filtration → Membrane Concentration → Ultra-Fine Spray Drying → 80 Mesh Sifting → Nitrogen Sealing → QC Analysis.
10. Storage & Packaging
Packed in 25kg standard fiber drum with double-layered PE bags. Store at <25°C. Highly hygroscopic powder; avoid all moisture contact. Shelf life: 24 months.
11. MOQ, Sample & Global Shipping
MOQ: 25kg bulk. 100g trial samples with HPLC fingerprint available. Global air/sea dispatch within 3-5 days. CIF/DDP support.
12. Scientific Research & Clinical Data
Clinical data confirms that oral intake of 1000mg standardized Lion’s Mane supports cognitive task accuracy. Research confirms fruiting-body extracts contain the mandatory hericenones absent in laboratory-mycelium.
13. Applicable Industries
Neuro-Supplements
Functional Coffee
Nootropic OEM
16. Supplier Comparison & Procurement Guide
| Metric | Standard Mycelium-on-Grain | Exbiol® Fruiting Body Tech |
|---|
| Alpha-Glucan (Starch) | 30% – 60% filler | ≤ 1.0% (Starch-Free) |
| Active Hericenones | Trace / Unquantified | ≥ 3.0% HPLC Verified |
| Traceability | Broker Sourcing | DNA Verified Isolate |
17. Technical FAQ for Bulk Buyers
Q: How do you verify the 3% assay vs. simple ratios like 10:1?
“10:1” is an extraction ratio, not an active content guarantee. We utilize HPLC-DAD with an internal hericenone standard to quantify the biological power of the lot, ensuring neuro-efficacy.
Q: Is your extract 100% Fruiting Body or Mycelium?
It is 100% Fruiting Body. We utilize DNA Barcoding to ensure zero mycelium or grain filler is present, which is the only way to deliver standardized hericenone levels.
Q: What prevents ‘clumping’ in functional coffee mixes?
We maintain moisture ≤5.0% and particle size at 80 mesh. Our crystallization process minimizes natural hygroscopicity, ensuring instant dispersion in hot or cold liquids.
Q: Is it non-GMO verified?
Yes, all our Hericium erinaceus strains are non-genetically modified and grown in GAP mountain logs.
Q: How do you control heavy metals in mushrooms?
Mushrooms are bio-accumulators. We use **Membrane Separation** during extraction to filter out trace Lead and Arsenic, meeting the strictest EU 1881/2006 limits.
18. References & Regulatory Sources
PubMed: Neuro-trophic activity of hericenones. | FDA: GRAS database for mushroom extracts. | ISO 22000 Quality Management.
Exbiol® Quality Assurance
Manufactured by Shaanxi Zhonghong Investment Technology Co., Ltd. 100% batch traceability from log to fiber drum. ISO & GMP Certified production.
✔ Hericenones ≥ 3.0% HPLC
✔ 100% Fruiting Body DNA
✔ 8,500kg Bulk Stock
📧 [email protected] | 🌐 www.exbiol.com
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