Erinacine A 1% Lion’s Mane Mycelium Extract
B2B Sourcing: streamlined R&D-to-commercial pathway with 1 kg evaluation and 25 kg commercial packaging. R&D & QA: active-marker HPLC verification, batch documentation and contaminant controls for technical qualification.
| SOURCE H. erinaceus | MATERIAL Mycelium | ASSAY ≥1.0% | METHOD HPLC | CAS MARKER 156101-08-5 |
1. Procurement & R&D Dual-Track Supply
| B — Sourcing / Procurement Focus: availability, MOQ, commercial packaging, lead time and logistics. Qualification can begin at 1 kg before scaling to 25 kg+. | A — R&D / Quality Focus: assay consistency, chromatographic evidence, identity, contaminants and batch documentation before formulation approval. |
2. What Is Erinacine A?
Erinacine A is a cyathane-type diterpenoid associated with Hericium erinaceus mycelium. It is chemically distinct from beta-glucans and total polysaccharides commonly used to characterize conventional Lion’s Mane ingredients.
3. Technical Specification
| Parameter | Specification | Control |
|---|---|---|
| Fungal Source | Hericium erinaceus | Identity documentation |
| Material | Mycelium | Manufacturing record |
| Erinacine A | ≥1.0% | HPLC |
| Loss on Drying | ≤9.0% | Gravimetric |
| Appearance | Yellow-brown fine powder | Organoleptic |
4. Controlled Liquid-Fermented Mycelium
Controlled submerged fermentation provides a scalable environment for producing H. erinaceus mycelium while supporting process control and active-marker standardization.
5. Mycelium vs. Fruiting Body
| Feature | Mycelium | Fruiting Body |
|---|---|---|
| Representative diterpenoids | Erinacines | Hericenones |
| Target on this page | Erinacine A ≥1% | Separate product profile |
6. Why HPLC Standardization Matters
| Marker Specificity Polysaccharide values alone cannot establish Erinacine A potency. | Batch Control Defined assay limits support lot-to-lot technical qualification. | R&D Traceability Chromatographic data supports formulation and QC review. |
7. HPLC Identity & Quantitative Verification
EXBIOL® qualification focuses on quantitative Erinacine A testing rather than extract-ratio claims. Technical review may include the batch assay, chromatographic profile, reference-standard information and applicable analytical method documentation.
8. Representative Active-Ingredient COA
| Item | Specification | Representative Result | Method |
|---|---|---|---|
| Erinacine A | ≥1.0% | 1.11% | HPLC |
| Loss on Drying | ≤9.0% | 3.11% | Gravimetric |
| Appearance | Fine powder | Conforms | Visual |
9. Heavy-Metal Control — ICP-MS
Recommended in-house release specification; replace with actual batch results when published.
| Element | Specification | Method |
|---|---|---|
| Lead (Pb) | ≤3.0 mg/kg | ICP-MS |
| Arsenic (As) | ≤2.0 mg/kg | ICP-MS |
| Cadmium (Cd) | ≤1.0 mg/kg* | ICP-MS |
| Mercury (Hg) | ≤0.1 mg/kg | ICP-MS |
*Confirm the Cd specification against the final approved product COA before publication.
10. Pesticide Residue Screening
Recommended technical qualification framework; final MRL requirements depend on destination market.
| Screen | Acceptance | Method |
|---|---|---|
| Organochlorine Pesticides | Conforms to agreed MRL | GC-MS/MS |
| Organophosphate Pesticides | Conforms to agreed MRL | GC-MS/MS |
| Pyrethroids | Conforms to agreed MRL | GC-MS/MS |
| Carbamates | Conforms to agreed MRL | LC-MS/MS |
| Multi-Residue Screen | Destination-market specification | GC-MS/MS + LC-MS/MS |
11. Microbiological Release Control
| Test | Recommended Specification | Method |
|---|---|---|
| Total Aerobic Count | ≤1,000 CFU/g | USP <61> |
| Yeast & Mold | ≤100 CFU/g* | USP <61> |
| E. coli | Negative | USP <62> |
| Salmonella | Negative | USP <62> |
*Confirm final yeast/mold release limit with the approved specification before publication.
12. Manufacturing Flow & Process Control
13. Formulation Applications
| Capsules & Tablets Marker-defined cognitive and healthy-aging formulations. | Powder Blends Functional mushroom and nootropic systems. | R&D Prototypes Pilot formulation and stability evaluation. |
14. Packaging, Storage & Shelf Life
| PACKAGING 25 kg Drum | SHELF LIFE 24 Months | STORAGE Cool & Dry | PROTECTION Heat / Light / Moisture |
15. MOQ, Lead Time & Global Logistics
| EVALUATION 100 g | R&D 1 kg | COMMERCIAL 25 kg+ | LOGISTICS CIF / DAP / DDP |
16. Technical Dossier & Regulatory Support
| Core Documents COA • TDS / Specification • SDS • Manufacturing Flow • Batch Traceability | Analytical Support HPLC • Chromatogram • Heavy Metals • Microbiology • Project-Specific Testing |
This material is controlled against an in-house specification. USP, EP and BP should not be claimed as product monographs unless formally applicable.
17. Scientific Evidence & Responsible Positioning
Research includes cell, animal, pharmacokinetic and early human studies involving Erinacine A or Erinacine-A-enriched H. erinaceus mycelium. A published pilot double-blind study used Erinacine-A-enriched mycelial capsules, while other research has demonstrated strong strain-dependent variation in Erinacine A production.
18. Buyer Qualification Checklist & FAQ
How is Erinacine A 1% verified?
Quantitative HPLC testing is used for active-marker control. Batch-specific COA and chromatographic documentation can be supplied for qualification.
Is the material mycelium or fruiting body?
This product is based on Hericium erinaceus mycelium produced through controlled liquid fermentation.
Can we evaluate 1 kg before commercial scale?
Yes. The qualification pathway supports evaluation material and a 1 kg R&D order before 25 kg+ commercial supply.
Can EXBIOL provide COA, TDS, SDS and HPLC data?
Yes. Documentation can be prepared according to the project stage and technical qualification requirements.
Is Erinacine A the same as total Lion’s Mane polysaccharides?
No. Erinacine A is a specific diterpenoid marker and requires marker-specific analytical verification.
19. Scientific References & Technical Review
- Li I-C et al. Erinacine A-enriched Hericium erinaceus mycelia pilot double-blind study. PMID: 32581767.
- Liu M et al. Isolation and evaluation of Erinacine A contents in Hericium erinaceus mycelial strains. PMID: 38890878.
- Published pharmacokinetic investigations of Erinacine A and tissue distribution.
Scientific references are provided for technical background and should not be interpreted as disease-treatment claims for the commercial ingredient.
Qualifying Erinacine A? Start With the Batch Data.
Send your target specification, annual volume, destination market and formulation format. EXBIOL® can prepare the appropriate technical package for procurement, QC and R&D review.
