Maintain 100% production uptime with our 5,500kg ready-to-ship inventory. We resolve “Line-Down” risks for Piceatannol wholesale buyers with 72-hour dispatch to US/EU ports.
Validate your longevity formula with HPLC-DAD Isomer Fingerprinting. Strictly PAH4 compliant (EU 2023/915). Tapped density optimized for high-speed automated lines.
Industrial Technical Investigation Hub
Industrial Engineering Dashboard
10083-24-6
≥ 3.5% Piceatannol
0.48 g/mL
≤ 10 ppb
Non-Detected (ND)
EU 2023/915
1. What is Piceatannol (Passion Fruit Seed Extract)?
Piceatannol (3,3′,4,5′-tetrahydroxystilbene) is a naturally occurring stilbenoid analog of Resveratrol, primarily isolated from the seeds of Passiflora edulis. In the industrial longevity and metabolic health sectors, Piceatannol is recognized as a “Next-Generation Stilbenoid” with significantly higher oral bioavailability than Resveratrol. Exbiol® provides a **Titrated Extract (Passienol™ grade)** standardized to ≥3.5% Piceatannol, specifically engineered to pass the most rigid EFSA and French Customs audits for European market entry.
2. Technical Specifications
Industrial grade 3.5% isolate. Optimized for clean-label supplements. Verified 100% natural origin via H-NMR.
3. Source & Botanical Pedigree
Exbiol® sources authentic Passiflora edulis Sims seeds through our sustainable upcycling program. By utilizing the seed matrix, we concentrate stilbenoids that are absent in the fruit pulp. Every batch originates from our high-security Shaanxi hub, using food-grade ethanol/water systems to ensure a non-GMO, Hexane-free raw material base.
4. Mechanism of Action
Piceatannol functions as a potent **Sirtuin-1 (SIRT1) activator**, even at lower concentrations than Resveratrol. Its unique hydroxyl group at the 3′ position increases its hydrophilic index, supporting superior functional properties in modulating adipogenesis and enhancing cellular functional defense against oxidative glycation (AGEs).
5. Application Benefits
- Metabolic Support: Functional property for supporting healthy insulin sensitivity.
- Dermal Vitality: May support the functional property of stimulating Type I collagen synthesis.
- Bio-Bioavailability: 2x higher metabolic flux compared to traditional trans-resveratrol bulk.
Advanced Engineering Systems
PAH4 Removal Technology
Industrial challenge: Fruit seed extracts often carry high Polycyclic Aromatic Hydrocarbons. Exbiol® utilizes Multi-column Molecular Filtration to reduce Benzo(a)pyrene to < 2 ppb, fulfilling EU Regulation 2023/915 for premium supplement safety.
Carrier System Engineering
We stabilize the fragile Piceatannol molecule. By utilizing Non-GMO Maltodextrin Shielding, we prevent the “Browning” oxidation of stilbenoids during storage, ensuring a 36-month shelf life with >99% active retention.
ETO-Free Assurance
For R&D giants in the EU, we provide a 100% negative Ethylene Oxide (ETO) guarantee. Every industrial batch is tested via GC-MS, removing the risk of customs rejection in rigid markets like France and Belgium.
6. Usage & Formulation Guide
Solubility: Dispersible in water. Soluble in Ethanol and PG. R&D Recommendation: Best formulated in hard-shell capsules or functional dry-mixes. pH Range: Structural integrity maintained from pH 3.0 to 6.5. Temperature: Avoid prolonged exposure >60°C.
7.Technical Evidence & Batch Performance
HPLC-DAD Fingerprint
[Illustrative Engineering Simulation] Documenting ≥3.5% Piceatannol isolate purity with zero synthetic Resveratrol spiking detection limit.
40°C Stability Simulation
Color and assay stability verified under ICH Zone IVB conditions. Potency retention ≥ 98.4% after 180 days.
8.Section 8: Pharma-Grade Analytical COA Matrix
8.1 Identity & Assay Profile
| Testing Item | Industrial Specification | Test Method | Standard |
|---|---|---|---|
| Assay (Piceatannol) | ≥ 3.5% | HPLC-DAD | In-house |
| Identification | Positive Match | HPLC / HPTLC | USP Reference |
8.2 Physical & Flowability Analysis
| Testing Item | Specification | Method |
|---|---|---|
| Bulk Density | 0.40 – 0.60 g/mL | USP <616> |
| Tap Density | 0.55 – 0.80 g/mL | USP <616> |
| Mesh Size | 100% through 80 Mesh | Sieve Analysis |
8.3 Safety & Residue Control
| Item | Spec (mg/kg or ppb) | Method |
|---|---|---|
| Lead (Pb) | < 3.0 ppm | ICP-MS |
| Benzopyrene | < 10 ppb | GC-MS/MS |
| Ethylene Oxide | Non-Detected | GC-MS |
8.4 Microbiological Standards
| Analysis | Specification | Method |
|---|---|---|
| TAMC | < 10,000 cfu/g | USP <61> |
| Salmonella | Negative in 25g | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Packed in 1kg/5kg Al-foil bags; 25kg standard fiber drums with double PE inner liners. Store at <25°C. Shelf life: 36 months.
11. MOQ, Sample & Global Shipping
MOQ: 25kg bulk. 50g samples available with full HPLC chromatogram. Global dispatch within 3-5 working days. Full CIF/DDP support for Tier-1 markets.
12. Scientific Research & Clinical Data
Research published in the Journal of Agricultural and Food Chemistry demonstrates Piceatannol’s high affinity for cellular sirtuin receptors. Scientific research confirm it is a superior active for UV-damaged skin recovery formulations compared to resveratrol bulk isolate.
13.Regulatory & Compliance Decision Tree
FDA / DSHEA
↓
GRAS / Dietary Supplement
Novel Food
↓
EFSA / EC No 396/2005
FOSHU
↓
Functional Food Claims
14. B2B Application Scenarios: Professional OEM/ODM Solutions
Exbiol® Passienol™ grade Piceatannol is engineered for high-performance manufacturing environments. We provide three specific application matrices:
Our 80-100 mesh distribution ensures zero “bridging” in automatic capsule-filling hoppers. Ideal for standalone 50mg-100mg metabolic support formulas.
Low moisture content (≤6.0%) prevents the cross-linking of gelatin shells, a common failure point in lipid-based stilbenoid products.
Purified via molecular filtration to remove dark pigments, allowing for high-dose inclusion in skin-brightening serums without affecting emulsion color.
15. Industrial Market Applications: Global Regulatory Trends
The global stilbenoid market is currently pivoting from Resveratrol toward **Piceatannol** due to the latter’s superior metabolic flux (2x higher bioavailability). For brands targeting the **Healthy Aging** and **Metabolic Syndrome** categories, Piceatannol offers a “Next-Gen” competitive advantage.
Tier-1 brands in the USA and Europe are increasingly moving toward **Upcycled Ingredients**. By using Passion Fruit Seeds (a byproduct of the juice industry), Exbiol® helps your brand satisfy **ESG (Environmental, Social, and Governance)** mandates while delivering pharmaceutical-grade efficacy. This “Circular Beauty/Nutrition” narrative is a primary driver for retail placement in Premium Natural channels.
16. Market Benchmark Comparison
| Metric | Standard Generic Extract | Exbiol® Passienol™ Grade |
|---|---|---|
| PAH4 Residue | ~ 150 – 300 ppb | ≤ 50 ppb (EU Regulation) |
| Solvent Origin | Methanol/Hexane Mix | 100% Ethanol/Water Only |
| Solubility | Partial / Sediment | Stabilized CWD Dispersion |
| Regulatory | Basic COA | USP-Audited Tech Dossier |
17. Technical Procurement FAQ
Q: How do you verify the 3.5% assay vs. simple ratios like 10:1? (Ref: Section 05)
“10:1” is an extraction ratio, not an active content guarantee. We utilize HPLC-DAD with an internal Piceatannol reference standard to quantify the lot, ensuring neuro-efficacy and 1:1 match with research data.
Q: Is your Piceatannol stable for high-heat industrial baking? (Ref: Section 11)
Yes, our Piceatannol is thermally stable up to 160°C. For industrial baking, we recommend reducing oven temperature by 10°C to achieve optimal stilbenoid retention.
Q: How is PAH4 controlled in bulk production? (Ref: Section 08)
We utilize secondary column chromatography to specifically trap PAH4 molecules. This ensures the sum of PAH4 is ≤ 50 ppb, compliant with the strictest French Customs and EFSA safety guidelines.
18. References & Regulatory Sources
- PubMed: Bioavailability of Piceatannol stilbenoids in humans.
- EFSA: Panel on Food Additives and Nutrient Sources.
- USP / EP / ICH Guidelines for Stilbenoid Purity management.
Exbiol® Quality Assurance
Manufactured by Shaanxi Zhonghong Investment Technology Co., Ltd. 100% batch traceability from seed to fiber drum. ISO 9001 & GMP Certified operations.
✔ PAH4 / ETO-Free Verified
✔ 5,500kg Bulk Stock Ready
