Sourcing Solution
Eliminate production downtime with Exbiol® global logistics. We maintain 5,000kg ready-stock for 3-5 day dispatch. 1kg R&D samples available immediately.
Engineering Support
Solve the “Synthetic vs. Natural” audit. We provide 100% Polyamine Fingerprinting (Spermidine, Spermine, Putrescine) via high-resolution HPLC-FLD.
As the life-science division of Zhonghong Group, Exbiol® specializes in high-purity Natural Spermidine (CAS 124-20-9). Our non-GMO wheat germ isolate is standardized to 1.0% HPLC, ensuring full batch traceability and molecular integrity for Tier-1 longevity brands.
124-20-9
Spermidine ≥ 1.0%
Yellowish Powder
Aqueous Clarity
3-7 Days
GMP / ISO / FDA
Natural Spermidine Water Solubility & Clarity Matrix
Exbiol Natural Spermidine is engineered for 100% aqueous clarity. Utilizing our proprietary CWD (Cold Water Dispersible) technology, our bulk spermidine powder ensures zero sedimentation and peak biological predictability in liquid nutricosmetic shots and functional beverages.
● 100% CLEAR_PASS
| Solvent System | pH Range | Concentration | Exbiol Status |
|---|---|---|---|
| Purified Water (25°C) | 3.0 – 7.0 | 50 mg/mL | 100% Transparent |
| Ethanol / Hydro-alcoholic | 4.5 – 6.5 | 20 mg/mL | Fully Miscible |
| Formulation Base (Serums) | 5.5 – 6.0 | Target Dose | Stable / No Caking |
💡 Expert Lab Note: To maximize Spermidine water solubility, avoid high-alkaline environments (pH > 8.0) which may trigger molecular habit shifts. Our botanical ingredients factory provides pre-solubilized liquid concentrates upon request.
1. What is Natural Spermidine?
Natural Spermidine is a polyamine compound extracted from the germ of Triticum aestivum. It is a vital autophagy activator that mimics the physiological effects of fasting. Unlike synthetic versions, Exbiol® Natural Spermidine contains supporting polyamines (Spermine, Putrescine), providing superior bio-mimicry for cellular renewal.
2. Technical Specifications Table
| Marker Compound | Standard (HPLC-FLD) |
|---|---|
| Active Spermidine | ≥ 1.0% |
| Total Polyamines | ≥ 1.5% |
| Gluten Residue | Controlled Standard |
3. Source & Botanical Origin
Exbiol® Natural Spermidine is derived exclusively from Non-GMO Wheat Germ. We utilize DNA Barcoding verification to ensure the biomass is authentic Triticum aestivum. Our vertical supply chain selects only the high-polyamine fraction of the germ, harvested at peak physiological potency to ensure the highest yield of free-form spermidine before industrial milling.
4. Mechanism of Action (Mitophagy Activation)
Spermidine functions by inhibiting the acetyltransferase EP300, which induces systemic autophagy. At a molecular level, it activates the PINK1/Parkin-mediated pathway, which identifies and clears dysfunctional mitochondria. This mechanism may support mitochondrial fitness and proteostasis, supporting functional defense against cellular senescence signaling.
5. Application Benefits
- Longevity Active: Functional property for systemic cellular detoxification via autophagy.
- Dermal Integrity: May support the functional property of hair follicle stimulation and epidermal thickness.
- Cognitive Support: Functional active in supporting neuro-synaptic integrity.
- Bio-Compatible: 100% plant-derived matrix ensures high metabolic affinity.
6. Usage & Formulation Guide
Dissolution: Exbiol® Spermidine is Cold Water Dispersible (CWD). It achieves instant aqueous clarity in room-temperature formulations.
pH Stability: Maintains molecular integrity between pH 3.0 and 6.5. In alkaline environments (pH > 7.5), polyamines are prone to auto-oxidation.
Temperature Control: Thermolabile. Do not exceed 50°C during industrial mixing to prevent polyamine degradation. Add to the final stage of formulation.
7. Industrial Evolution
The industry has transitioned from crude wheat germ oils (low bioactive concentration) to second-gen raw powders. Exbiol® represents the Third-Generation Standarized Isolate, utilizing membrane filtration to remove gluten-associated proteins while maximizing the free-form polyamine fraction for industrial-scale encapsulation and beverage stability.
8. COA & Quality Control Specifications
Table 8.1: Heavy Metals Analysis
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| Arsenic (As) | < 0.1 ppm | ICP-MS |
| Mercury (Hg) | < 0.1 ppm | ICP-MS |
Table 8.2: Pesticide & Solvent Residue
| Item | Spec | Method |
|---|---|---|
| Total Pesticides | Negative | GC-MS/MS |
| Residual Ethanol | < 500 ppm | GC-HS |
| Aflatoxin B1 | < 2.0 ppb | HPLC-MS |
Table 8.3: Microbiological Standards
| Item | Spec | Method |
|---|---|---|
| Total Plate Count | < 1,000 cfu/g | USP <61> |
| Pathogenic Bacteria | Negative | USP <62> |
9. Manufacturing Flow Description
10. Storage & Packaging
Bulk Supply: 25kg standard fiber drum with nitrogen-sealed multi-layer PE liner. Store at <20°C in a dry environment. Polyamines are extremely sensitive to UV and moisture; keep containers airtight. Shelf life: 24 months.
11. MOQ, Sample & Global Shipping
MOQ: 25kg. Trial orders of 1kg supported for industrial R&D. Global Air Freight (DHL/FedEx) available with 3-5 day transit. Certified DDP/CIF terms for EU/North America hubs.
12. Scientific Research & Clinical Data
Human trials published in FEBS Letters demonstrate that oral intake of 1mg/day natural spermidine bypasses the “Non-Producer” microbiome issue, accumulating in human tissue within 30 days. Research suggests its functional property in supporting cardiovascular aging markers via vascular autophagy.
13. Applicable Industries
Nootropics
Nutricosmetics
Anti-aging Skincare
14. B2B Application Scenarios
Optimized for Contract Manufacturers (OEM/ODM) developing anti-aging hair serums, mitochondrial renewal capsules, and high-clarity longevity energy shots. Our powder ensures zero “cereal-off-notes” in delicate flavor profiles.
15. Industrial Market Applications
Target the high-growth Biohacking and Geroscience market segments. Exbiol® provides the raw material transparency required for “Clean Label” certification in whole-food retail markets (Whole Foods, Erewhon standards).
16. Supplier Comparison & Procurement Guide
| Metric | Standard Industry Grade | Exbiol® Phyto-Tech |
|---|---|---|
| Purity Method | UV-Vis (Inaccurate) | HPLC Fingerprint (FLD) |
| Solvent residue | Methanol traces | 100% Ethanol/Water Only |
| Inventory | Lead time 4-6 weeks | 5,000kg Ready-to-Ship |
17. Technical FAQ for Bulk Buyers
Q: How does your polyamine ratio compare to the USP standard?
Every bulk batch strictly matches the pharmaceutical fingerprint for wheat germ: Spermidine (≥1.0%), Spermine (≥0.1%), and Putrescine (trace). We provide a 3-marker chromatogram with every COA to prove authenticity.
Q: Is your Spermidine stable in hot-fill beverage processing?
No. Polyamines oxidize at high temperatures. For RTD production, we recommend our specialized Nano-Stabilized Liquid or adding the powder after the cooling phase (<45°C) to maintain autophagy activity.
Q: What is the regulatory status of Natural Spermidine in the EU?
Natural Wheat Germ Extract rich in Spermidine is recognized as a traditional food ingredient in most jurisdictions. For specific health claims, we provide full dossiers supporting “Cellular Renewal” and “Autophagy” safety profiles.
Q: Does Exbiol provide DNA verification for its raw materials?
Yes. To prevent adulteration with cheaper grains, we perform DNA Barcoding (rbcL/matK) on every harvest of wheat germ before extraction.
Q: Can you ship bulk tonnage to our North American hub within 7 days?
Yes. We utilize strategic warehousing in LA and NJ. For in-stock tonnage, dispatch occurs within 24 hours, with 3-5 day transit to regional factory hubs.
Q: What is the specific rotation [α]D20 of your Spermidine isolate?
For our high-purity isolate (≥10%), the specific rotation is verified to ensure zero racemic synthesis contamination, maintaining 100% biological activity.
18. References & Regulatory Sources
- PubMed: Induction of autophagy by dietary spermidine.
- FDA: GRAS Notice for Wheat Germ Extracts (Metabolite Verification).
Exbiol® Quality Assurance
Manufactured by Shaanxi Zhonghong Investment Technology Co., Ltd. Every batch is 100% traceable from seed source to the final fiber drum. ISO 9001 & GMP Certified factory operations.
✔ Full COA Verification
✔ OEM/ODM Customization
