Olive Leaf Extract Manufacturer | Bulk Oleuropein 20% 40% | Wholesale High-Purity Supply
Global Industrial Manufacturing of Standardized Olea Europaea Phytochemicals.
As the life-science division of Zhonghong Group, Exbiol® leverages 29 years of phytochemical engineering to provide premium Olive Leaf Extract bulk supply. For Sourcing Managers, we resolve production delays with a 15,000kg ready-stock inventory and 3-7 day global dispatch. For R&D Giant-level demands, we offer HPLC-verified Oleuropein (up to 80%) and Hydroxytyrosol (up to 20%) with zero solvent residue. Our GMP-certified facility ensures 100% molecular consistency and audit-ready documentation (MSDS, TDS, COA) for global pharmaceutical and nutricosmetic leaders.
1. What is Olive Leaf Extract?
Olive Leaf Extract is a concentrated phytochemical active derived from the leaves of the Olea europaea tree. In the industrial sector, it is valued for its unique secoiridoids, primarily Oleuropein and Hydroxytyrosol. Unlike crude powders, our standardized extract is engineered via low-temperature vacuum extraction to preserve the delicate antioxidant matrix, making it a gold-standard active for cardiovascular and immune support.
2. Technical Specifications Table
| Parameter | Standard / Specification |
|---|---|
| Active Content (HPLC) | Oleuropein 10%-80% | Hydroxytyrosol 1%-20% |
| Specific Rotation [α]D20 | -185.0° to -195.0° (Verification of Purity) |
| Mesh Size | 100% Through 80 Mesh |
| Loss on Drying | ≤ 5.0% |
3. Source & Origin
Our biomass is harvested from high-yield Olea europaea groves in the Mediterranean basin and our Shaanxi GAP-compliant zones. We utilize a “Green-to-Dried” time-locked protocol to ensure leaves are processed within 24 hours of harvest, preventing the degradation of heat-sensitive phenols.
4. Mechanism of Action
Oleuropein and Hydroxytyrosol function as potent free-radical scavengers by donating hydrogen from their phenolic hydroxyl groups. At a molecular level, they modulate the eNOS/iNOS expression, supporting healthy vascular endothelial function and mitochondrial property support (mitophagy).
5. Application Benefits
- Vascular Health: May support functional blood pressure maintenance.
- Immune Defense: Functional property for cellular defense against viral stressors.
- Dermal Aging: High-ORAC value active for anti-pollution skincare formulations.
6. Usage & Formulation Guide
Solubility: 100% Water-Soluble. Ideal for clear liquid shots and syrups.
pH Stability: Maintain formulation between pH 3.0 and 6.0. In alkaline environments (>pH 7.0), polyphenols may undergo auto-oxidation, causing a dark brown discoloration.
Process Temp: Add during the cooling phase (<50°C) to maintain isomer integrity.
7. Industrial Evolution
The industry has evolved from crude ground leaf to modern Hydroxytyrosol-enriched liquid-solid isolates. Exbiol® represents the fourth generation, utilizing Advanced Membrane Separation to isolate small-molecule phenols, ensuring high bioavailability and zero heavy-metal accumulation.
8. COA & Quality Control Specifications
Table 8.1: Heavy Metals (ICP-MS)
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 1.0 ppm | ICP-MS |
| Arsenic (As) | < 0.5 ppm | ICP-MS |
| Mercury (Hg) | < 0.1 ppm | ICP-MS |
Table 8.2: Pesticide Residue (Multi-Screen)
| Item | Spec | Method |
|---|---|---|
| Organochlorines | Negative | GC-MS/MS |
| Total Pesticides | < 0.01 mg/kg | USP <561> |
Table 8.3: Microbiological Standards
| Item | Spec | Method |
|---|---|---|
| Total Plate Count | < 1,000 cfu/g | USP <61> |
| Salmonella | Negative | USP <62> |
9. Manufacturing Flow
Harvest → Air-Drying → Ethanol/Water Extraction → Ultra-filtration → Concentration → Column Chromatography Separation → Low-Temp Spray Drying → Testing → Packaging.
10. Storage & Packaging
Bulk Supply: 25kg fiber drum with double-layered light-blocking PE liners. Store at <25°C, humidity <60%.
11. MOQ, Sample, Global Shipping
MOQ: 25kg. 10g-50g free samples for lab evaluation. Global air/sea freight from Shanghai/Qingdao within 3 working days.
12. Clinical Data & Scientific Research
In-vitro research indicates standardized Oleuropein increases the glucose utilization rate in skeletal muscle cells. Comparative studies demonstrate its ORAC value is 400% higher than Vitamin C (Ascorbic Acid).
13. Applicable Industries
Dermaceuticals
Veterinary Medicine
14. B2B Application Scenarios
Contract manufacturers (OEM/ODM) utilize our bulk extract for Cardiovascular Support Capsules, Immunity-Boost Liquid Shots, and Post-Sun Skin Recovery Serums.
15. Industrial Market Scenarios
In the Mediterranean Longevity marketing trend, Olive Leaf Extract is a core differentiator for brands seeking health-claim-compliant formulations in the EU and North American markets.
16. Sourcing Guide
R&D Audit Check: HPLC Fingerprint Verification.
Some suppliers spike extracts with pure Oleuropein isolate. Exbiol® guarantees 100% botanical fingerprinting via HPTLC, ensuring all natural phenolic co-factors remain present for the true “Entourage Effect.”
17. Technical FAQ
Q: Is your extract water-soluble for beverages?
A: Yes, our Refined Grade provides 100% clarity in aqueous solutions without sedimentation.
Q: What is the difference between Oleuropein and Hydroxytyrosol?
A: Oleuropein is the precursor secoiridoid; Hydroxytyrosol is the highly bioavailable metabolite with higher antioxidant capacity.
Q: Does it contain Methanol?
A: No. We use 100% food-grade Ethanol and Water for extraction.
Q: How do you control PAH4 residues?
A: We utilize active carbon membrane filtration to keep PAHs below 10ppb, meeting EU 2015/1933 standards.
Q: Is your material Non-GMO?
A: Yes, all Olive Leaves are non-genetically modified.
Q: What is the shelf life?
A: 24 months when stored in original unopened nitrogen-flushed containers.
18. References
- PubMed: Phenolic compounds in Olea europaea and health benefits.
- FDA GRAS database for Olive Leaf Extract.
- USP Monographs for Botanical Ingredients.
Olive Leaf Extract Manufacturer & QA
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified specialist in high-purity botanical actives.
✔ Full Batch COA & PAH Compliance
✔ 15,000kg Bulk Stock Ready
