In my 29 years of navigating the phytochemical corridors from Shaanxi to the global supplement stage, I’ve witnessed the rise of “Longevity Molecules.” However, for brands like Niagen or Cargill, the challenge isn’t finding these molecules—it’s ensuring Molecular Identity and Pharmacokinetic Consistency.
At Exbiol (A ZHONGHONG Group Brand), we don’t just supply ingredients; we provide formulation-ready intelligence. Below, we disclose the technical benchmarks for our flagship longevity portfolio: Urolithin A and the Spermidine series.
Urolithin A: Mitophagy Induction Verified by Molecular Purity
Urolithin A (CAS 1143-70-0) is a major metabolite of ellagitannins. Generic 98% extracts often contain residual pomegranate fractions that interfere with stability.
- Exbiol Standard: We utilize HPLC-DAD to ensure a minimum purity of 99.2%.
- 1H-NMR Verification: Every batch is verified via Bruker 1H-NMR Spectrum analysis to ensure zero synthetic isomer contamination, guaranteeing maximum activation of mitochondrial autophagy.
The Spermidine Paradox: Free Base 99% vs. Trihydrochloride (3HCl)
Sourcing managers often struggle to choose between formats. Here is the technical breakdown from our R&D lab:
1. Spermidine Free Base 99% (Liquid/Solid)
- Technical Advantage: Highest elemental concentration. Ideal for advanced liquid formulations and liposomal delivery systems.
- Handling Requirement: Requires Nitrogen-blanketing and specialized OEB-4 containment due to its hygroscopic nature.
2. Spermidine Trihydrochloride (3HCl)
- Technical Advantage: Maximum stability for solid dosages (capsules/tablets).
- Exbiol Precision: We ensure a consistent Chloride salt ratio, preventing the common “formulation fallout” seen in generic 3HCl supplies.
Technical Matrix: Exbiol Longevity Ingredients
| Ingredient | CAS Number | Assay (HPLC) | Physical Form | Certification |
| Urolithin A | 1143-70-0 | ≥99.0% | Fine Powder | GMP, ISO, Kosher |
| Spermidine Free Base | 124-20-9 | ≥99.0% | Viscous / Crystalline | OEB-4 Handling |
| Spermidine 3HCl | 334-50-9 | ≥98.5% | White Powder | USP/EP Compliant |
Why Technical Sourcing Directors Trust Exbiol
Trust in the life sciences sector is built on Evidence.
- 29 Years of R&D: Our team understands the degradation kinetics of polyamines and urolithins in various pH environments.
- Solvent Control: Strictly compliant with USP <467> Class 2/3 limits.
- Global Logistics: Ready-to-ship bulk stock maintained in our US (New York) and Canada (Ontario) hubs for 3-5 day delivery.
💡 [B2B Conversion Hook]
Need a batch-specific 1H-NMR spectrum or a 24-month stability report?📑 [Request a Technical Dossier & Sample]🏭 [Inquire for 500kg+ Bulk Pricing]
FAQ: Sourcing High-Purity Longevity Actives
Q: How do you prevent the oxidation of Spermidine Free Base during transit?
A: Potency is preserved via vacuum-sealing in multi-layer OPA/ALU/PE bags with a nitrogen blanket. We provide stability data proving zero degradation over 24 months when stored at 2-8°C.
Q: Can Exbiol provide custom particle sizes for Urolithin A?
A: Yes. We offer Micronization (D90 < 10μm) via air-jet milling to solve the inherent low-solubility challenges of Urolithin A, enhancing its bioavailability in your finished formulation.
Disclaimer: This information is for industrial B2B use only. These technical statements have not been evaluated by the FDA or EFSA.
