Resveratrol Manufacturer | Bulk 98% Trans-Resveratrol | Wholesale Factory Supply
Standardized Polygonum Cuspidatum • USP/EP Grade • GMP Certified
Leading Global Manufacturing of High-Stability Trans-Resveratrol Solutions.
As the life-science division of Zhonghong Group, Exbiol® leverages 29 years of phytochemical engineering to provide premium Polygonum cuspidatum extract. We specialize in overcoming the “Isomer Stability Challenge” by offering bulk supply of Trans-Resveratrol standardized to 50%, 98%, and 99% (HPLC). Our GMP-certified facility ensures 100% molecular consistency, strictly controlling Emodin levels (<0.1%) and PAH residues to ensure audit-ready documentation (DMF/ASMF) for global pharmaceutical and longevity nutraceutical leaders.
1. What is Resveratrol (Trans-Resveratrol)?
Resveratrol is a polyphenolic phytoalexin known for its sirtuin-activating functional properties. In the industrial supply chain, we focus on Trans-Resveratrol (the bio-active form) vs. Cis-Resveratrol (the inactive byproduct). Exbiol® produces 98%+ pure Trans-isomer via proprietary crystallization, eliminating the anthraquinones (Emodin) typically found in lower-grade knotweed extracts.
2. Technical Specifications
| Testing Parameter | Industrial Standard (HPLC) |
|---|---|
| Trans-Resveratrol Content | ≥ 98.0% / 99.0% |
| Emodin (Anthraquinones) | ≤ 0.1% (Laxative-free Standard) |
| Particle Size | 100% through 80 Mesh (Micronized available) |
| Solvent Residue | Ethanol Only < 5000 ppm |
3. Source & Origin
Sourced from high-altitude Polygonum cuspidatum roots. We select biomass aged 3+ years to ensure optimal concentration of polydatin and resveratrol precursor molecules.
4. Mechanism of Action
Functions as a Sirtuin-1 (SIRT1) activator, mimicking the functional property of caloric restriction. It supports mitochondrial biogenesis via the PGC-1α pathway and inhibits lipid peroxidation.
5. Application Benefits
- Functional property for supporting cellular longevity.
- May support the reduction of UV-induced oxidative stress in topical applications.
- Standardized active for high-efficacy longevity and anti-aging supplements.
6. Industrial Formulation & Solubility Guide
Solubility Control: Resveratrol is hydrophobic. For liquid formulations, use cyclodextrin complexation or liposomal encapsulation. In oils, solubility is approx. 50mg/mL in Ethanol.
Stability Optimization: Highly sensitive to UV and alkaline pH (>7.0). Maintain acidic environments (pH 3.0-6.0) and use amber/opaque packaging.
7. Industrial Evolution of Resveratrol Extraction
The industry has evolved from crude root powder (50% Emodin) to first-gen solvent extracts, and now to Exbiol’s Third-Generation Isomer-Stabilized Crystallization. Our process utilizes multistage purification to eliminate Polycyclic Aromatic Hydrocarbons (PAHs) and heavy metals that typically accumulate in knotweed, moving from basic “Natural” labels to Pharmaceutical Grade Purity.
8. COA & Quality Control Specifications
| Toxin/Impurity | Limit | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| PAH4 (Benzopyrene etc.) | < 10 ppb (EU Standard) | GC-MS/MS |
| Emodin Residue | < 0.1% | HPLC |
9. Manufacturing Flow Chart
1. Raw Extraction: Ethanol/Water maceration of Polygonum Roots.
2. Concentration: Vacuum evaporation to remove crude fats.
3. Chromatography: Resin separation of Emodin and Trans-Resveratrol.
4. Crystallization: Repeated recrystallization to achieve 98%+ purity.
5. Drying: Low-temperature vacuum drying under Nitrogen blanketing.
6. Micronization: Sifting to 80-100 mesh standard.
10. Storage & Packaging Standards
Primary Packaging: 25kg Standard Fiber Drum with double-layered PE bags and Nitrogen-flush sealing.
Secondary: Aluminum vacuum-sealed bags for R&D samples (1kg).
Storage: Store at <25°C, Relative Humidity <60%. Keep away from UV radiation and strong oxidants.
11. Commercial Terms: MOQ & Global Shipping
- MOQ: 25kg (Standard Drum). Small batch trial orders (1kg) available for qualified labs.
- Samples: 10-50g free technical samples provided with COA.
- Global Dispatch: 3-7 day door-to-door air freight (DHL/FedEx) or ocean freight from Shanghai/Qingdao ports.
12. Clinical Data & Science Brief
In-vitro research suggests Trans-Resveratrol enhances autophagy and activates SIRT1. Human clinical trials (500mg-1500mg/day) demonstrate its safety profile and functional property in supporting cardiovascular health markers and metabolic equilibrium. No definitive medical treatment claims are implied.
13. Applicable Industries
Cosmeceuticals
Pharma APIs
Functional Food
14. Industrial B2B Application Scenarios
Our bulk Resveratrol is engineered for:
1. Direct Encapsulation: High-density powder for weight uniformity.
2. Serum Formulations: Ultra-fine mesh for better dispersion in oil-based cosmetic serums.
3. Premixes: Standardized for uniform blending in multivitamin complexes.
15. Manufacturing Use Case (Industry Perspective)
For large-scale softgel manufacturers, our Low-Emodin Resveratrol prevents cross-contamination issues and eliminates the common consumer complaint of digestive discomfort (laxative effect) found in lower-purity knotweed extracts.
16. Supplier Comparison Guide
Buyer Check: PAH4 and Benzopyrene Analysis
Cheap Resveratrol from contaminated areas often carries high PAH levels. Exbiol® guarantees PAH4 < 10ppb, meeting the strictest European food safety requirements.
17. Technical FAQ for Bulk Buyers (PAA Intercept)
A: Higher purity means less plant tannins and Emodin, ensuring better consumer compliance and easier formulation stability.
A: This is 100% natural extract from Polygonum cuspidatum. We also provide synthetic resveratrol upon request for specific pharma applications.
A: We use double-layered light-blocking PE bags and opaque drums to prevent Trans-to-Cis isomerization.
18. References & Regulatory Sources
• PubMed: Bioavailability of Resveratrol
• FDA: GRAS ingredient databases
• USP/EP Standards for Resveratrol
Resveratrol Manufacturer & QA
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified specialist in high-purity botanical actives.
✔ 98% Trans-Isomer Guaranteed
✔ Ultra-low Emodin & PAH Compliance
✔ Bulk Stock for Global Dispatch
