Natural Astaxanthin Manufacturer | Bulk 10% Oleoresin & CWD Powder | Wholesale Supercritical CO2 Supply
Leading Global Manufacturing of High-Stability Natural Astaxanthin Solutions.
As the life-science division of Zhonghong Group, Exbiol® leverages 29 years of phytochemical engineering to provide premium Natural Astaxanthin bulk supply. For Sourcing Managers, we eliminate “production-stop” risks with an 8,000kg ready-stock inventory for 3-5 day global dispatch. For R&D Specialists, we overcome the “Oxidation Paradox” by providing Supercritical CO2 Oleoresin (5%, 10%) and advanced CWD Nano-Powders with verified (3S, 3’S) isomer ratios. Our GMP-certified facility ensures zero solvent residue and 100% molecular consistency (USP/EP compliant) for Tier-1 global pharmaceutical and nutricosmetic leaders.
1. What is Natural Astaxanthin?
Natural Astaxanthin (CAS 472-61-7) is a high-value xanthophyll carotenoid derived from Haematococcus pluvialis microalgae. In industrial applications, it is recognized as the “King of Antioxidants” with a free-radical quenching capacity 6,000 times that of Vitamin C. Unlike petroleum-derived synthetic forms, Exbiol® Natural Astaxanthin is 100% esterified, providing superior biological stability and bio-availability for premium human health formulations.
2. Physicochemical Technical Specifications
| Analysis Item | Oleoresin (SFE-CO2) | CWD Powder (Nano) |
|---|---|---|
| Astaxanthin Content | 5.0% / 10.0% / 20.0% | 1.0% / 2.0% / 2.5% |
| Isomer Profile | ≥ 95% (3S, 3’S) | ≥ 95% (3S, 3’S) |
| Pheophorbide a | ≤ 20 mg/100g | ≤ 10 mg/100g |
| Solubility | Lipophilic (Oils/Fats) | Cold-Water Dispersible |
3. Source & Biological Origin
Sourced exclusively from Haematococcus pluvialis cultivated in closed photobioreactor (PBR) systems to prevent environmental contamination (pesticides/heavy metals). We utilize a hybrid stress-induction cycle—moving from the “Green Phase” expansion to the “Red Phase” carotenoid accumulation—ensuring maximum cellular density of trans-astaxanthin esters.
4. Mechanism of Action
Astaxanthin’s unique molecular structure allows it to span the entire cell membrane bilayer, neutralising reactive oxygen species (ROS) in both the hydrophilic and lipophilic layers. Unlike other antioxidants, it never becomes a pro-oxidant. This “biological bridge” mechanism may support mitochondrial functional properties and DNA integrity under high oxidative stress conditions.
5. Application Benefits (Regulatory Safe)
- Cellular Defense: Functional property for membrane-level lipid peroxidation inhibition.
- Dermal Health: May support the functional property of reducing UV-induced oxidative damage.
- Vision Support: Functional property related to blood-retinal barrier permeability support.
- Stability: Enhanced bio-efficacy through high-purity CO2 extraction.
6. Usage & Formulation Guide
Solubility Control: Oleoresin is ideal for softgel encapsulation. Use Nano-CWD Powder for beverages to ensure clarity and 100% suspension without “oil-ring” formation.
pH Sensitivity: Optimal stability maintained between pH 4.5 – 6.5. In highly acidic environments, micro-encapsulation is mandatory.
Processing: Avoid prolonged heating above 50°C. Nitrogen-blanketing is recommended during industrial mixing stages to prevent auto-oxidation.
7. Industrial Evolution
The industry has evolved from chemical solvent extraction (Ethyl Acetate/Acetone) to modern Supercritical CO2 Extraction (SFE). Exbiol® utilizes SFE because it eliminates toxic residues and operates at low temperatures, preserving the fragile antioxidant bonds and ensuring a “Clean Label” pharmaceutical-grade finish.
8. COA & Quality Control Specifications
Table 8.1: Heavy Metals (ICP-MS)
| Item | Spec | Method |
|---|---|---|
| Lead (Pb) | < 0.5 ppm | ICP-MS |
| Arsenic (As) | < 0.2 ppm | ICP-MS |
| Mercury (Hg) | < 0.1 ppm | ICP-MS |
Table 8.2: Pesticide Residue Multi-Screen
| Item | Spec | Method |
|---|---|---|
| Total Pesticides | Negative (400+ Screen) | GC-MS/MS |
| Aflatoxin B1 | Negative | HPLC-MS |
Table 8.3: Microbiological Standards
| Item | Spec | Method |
|---|---|---|
| Total Plate Count | < 1,000 cfu/g | USP <61> |
| Salmonella | Negative | USP <62> |
9. Manufacturing Flow Description
Algal Seed Cultivation → PBR Expansion → Raceway Stress Induction → Harvesting → High-Pressure Cell-Wall Cracking → Supercritical CO2 Extraction → Nitrogen Blanketed Standardization → Packing.
10. Storage & Packaging
Primary: Nitrogen-flushed Aluminum Bottles (1kg, 5kg) or vacuum-sealed PE bags (25kg drum). Store at 2-8°C for maximum shelf life. Avoid any UV exposure.
11. MOQ, Sample & Global Shipping
MOQ: 1kg for trial; 25kg for commercial batch. 50g samples available with isomer ratio certification. Dispatch within 3 working days via temperature-controlled air freight.
12. Clinical Data & Scientific Research
In-vitro research suggests Natural Astaxanthin has an ORAC (Oxygen Radical Absorbance Capacity) of 2,822,200 μmol TE/100g. Human studies published in PubMed demonstrate its safety profile in high-dose long-term supplementation.
13. Applicable Industries
Nutricosmetics
Aquaculture (Feed)
14. Industrial B2B Application Scenarios
Our bulk oleoresin is specifically filtered for high-speed softgel encapsulation machines to prevent needle clogging, while our CWD powder ensures zero oil-ring formation in functional beverages.
15. Industrial Market Scenarios
For brands targeting the Amazon/Retail “Brain & Vision” segment, choosing a CO2-extracted Astaxanthin provides the non-toxic, solvent-free marketing story required for high-conversion retail placement.
16. Supplier Comparison & Procurement Guide
| Criterion | Standard Industry Grade | Exbiol® SFE Technology |
|---|---|---|
| Solvent Residue | Acetone/Ethyl Acetate (Trace) | Zero (CO2 Only) |
| Oxidation Risk | High (Open-air drying) | Ultra-Low (Nitrogen-Lock) |
| Isomer Purity | Unquantified | ≥ 95% (3S, 3’S) Verified |
17. Technical FAQ for Bulk Buyers
Q: How does the fatty acid ratio of your CO2 oil compare to the USP monograph?
A: Every batch strictly adheres to the USP <2030> monograph, with a Trans-isomer ratio exceeding 90%. We provide a full GC/HPLC profile documenting the natural distribution of supporting carotenoids like Canthaxanthin and Lutein.
Q: Why is your Astaxanthin 10% Oleoresin flowable while others are paste-like?
A: We utilize a proprietary winterization step during extraction to remove high-melting-point waxes, easing the manufacturing process for softgel machines.
Q: What is the Pheophorbide a limit?
A: We keep it <20mg/100g, far below the standard for microalgal products, ensuring zero phototoxicity risk.
Q: Is your material Non-GMO?
A: Yes, our H. pluvialis is a non-genetically modified strain, grown with zero GMO-derived additives.
Q: Can I use your Astaxanthin in Gummies?
A: Yes, our Beadlet Grade is starch-coated to withstand the high-temperature boiling stage of pectin gummy production.
Q: What is the lead time for 500kg?
A: Standard dispatch is 3 working days from our Shaanxi hub.
18. References & Regulatory Sources
- PubMed: Astaxanthin isomers: Biological stability and bio-availability.
- FDA: NDI Notification for H. pluvialis Extract.
- EFSA: Novel Food Authorization for Astaxanthin Oleoresin.
- USP Monographs for Carotenoids.
Natural Astaxanthin Manufacturer & QA
Manufactured by Exbiol® (Shaanxi Zhonghong Investment Technology Co., Ltd.), a GMP-certified specialist in high-purity algal extracts for international industrial applications.
✔ 95% Trans-Isomer (3S, 3’S) Verified
✔ 8,000kg Bulk Stock Ready
✔ Global Batch Traceability
